Prospective memory and its correlates and predictors in schizophrenia: An extension of previous findings

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Title Prospective memory and its correlates and predictors in schizophrenia: An extension of previous findings
Author Ungvari, Gabor S; Xiang, Yu-Tao; Tang, Wai-Kwong; Shum, David
Journal Name Archives of Clinical Neuropsychology
Year Published 2008
Place of publication United Kingdom
Publisher Oxford University Press
Abstract Background: Prospective memory (PM) is the ability to remember to do something in the future without explicit prompts. Extending the number of subjects and the scope of our previously published study, this investigation examined the relationship between PM and socio-demographic and clinical factors, activities of daily living (ADL) and frontal lobe functions in patients with chronic schizophrenia. Methods: One hundred and ten Chinese schizophrenia patients, 60 from the previous study and 50 additional patients recruited for this study, and 110 matched healthy comparison subjects (HC) formed the study sample. Patients' clinical condition and activity of daily living were evaluated with the Brief Psychiatric Rating Scale (BPRS) and the Functional Needs Assessment (FNA). Time- and event-based PM tasks and three tests of prefrontal lobe functions (Design Fluency Test [DFT], Tower of London [TOL], Wisconsin Card Sorting Test [WCST]) were also administered. Results: Patients' level of ADL and psychopathology were not associated with PM functions and only anticholinergic medications (ACM) showed a significant negative correlational relationship with PM tasks. Confirming the findings of the previous study, patients performed significantly more poorly on all two PM tasks than HC. Performance on time-based PM task significantly correlated with age, education level and DFT in HC and with age, DFT, TOL and WCST in patients. Patients' performance on the event-based PM correlated with DFT and one measure of WCST. In patients, TOL and age predicted the performance on time-based PM task; DFT and WCST predicted the event-based task. Conclusions: Involving a large sample of patients with matched controls, this study confirmed that PM is impaired in chronic schizophrenia. Deficient PM functions were related to prefrontal lobe dysfunction in both HC and patients but not to the patients' clinical condition, nor did they significantly affect ADL. ACMs determined certain aspects of PM.
Peer Reviewed Yes
Published Yes
Publisher URI http://acn.oxfordjournals.org/
Alternative URI http://dx.doi.org/doi:10.1016/j.acn.2008.06.005
Volume 23
Page from 613
Page to 622
ISSN 0887-6177
Date Accessioned 2008-11-22
Date Available 2009-05-22T07:50:00Z
Language en_AU
Research Centre Griffith Health Institute; Behavioural Basis of Health
Faculty Griffith Health Faculty
Subject PRE2009-Biological Psychology (Neuropsychology, Psychopharmacology, Physiologica
URI http://hdl.handle.net/10072/22412
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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