Human health risk assessment of chlorinated disinfection by-products in drinking water using a probabilistic approach

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Title Human health risk assessment of chlorinated disinfection by-products in drinking water using a probabilistic approach
Author Hamidin, Nasrul; Yu, Jimmy; Connell, Des
Journal Name Water Research
Editor Mogens Henze (Editor-in-Chief)
Year Published 2008
Place of publication United Kingdom
Publisher Pergamon
Abstract The presence of chlorinated disinfection by-products (DBPs) in drinking water is a public health issue, due to their possible adverse health effects on humans. To gauge the risk of chlorinated DBPs on human health, a risk assessment of chloroform (TCM), bromodichloromethane (BDCM), dibromochloromethane (DBCM), bromoform (TBM), dichloroacetic acid (DCAA) and trichloroacetic acid (TCAA) in drinking water was carried out using probabilistic techniques. Literature data on exposure concentrations from more than 15 different countries and adverse health effects on test animals as well as human epidemiological studies were used. The risk assessment showed no overlap between the highest human exposure dose (EXPD) and the lowest human equivalent dose (HED) from animal test data, for TCM, BDCM, DBCM, TBM, DCAA and TCAA. All the HED values were approximately 104 to 105 times higher than the 95th percentiles of EXPD. However, from the human epidemiology data, there was a positive overlap between the highest EXPD and the lifetime average daily doses (LADDH) for TCM, BDCM, DCAA and TCAA. This suggests that there are possible adverse health risks such as a small increased incidence of cancers in males and developmental effects on infants. However, the epidemiological data comprised several risk factors and exposure classification levels, which may affect the overall results.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.watres.2008.02.029
Volume 42
Issue Number 13
Page from 3263
Page to 3274
ISSN 0043-1354
Date Accessioned 2009-02-17
Date Available 2011-11-03T06:15:33Z
Language en_AU
Research Centre Atmospheric Environment Research Centre
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Environmental Impact Assessment
URI http://hdl.handle.net/10072/22483
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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