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dc.contributor.authorGao, Jin
dc.contributor.authorL. Collard, Rachael
dc.contributor.authorBui, Loan
dc.contributor.authorC. Herington, Adrian
dc.contributor.authorNicol, David L.
dc.contributor.authorA. Clements, Judith
dc.date.accessioned2017-05-03T14:31:48Z
dc.date.available2017-05-03T14:31:48Z
dc.date.issued2007
dc.date.modified2009-04-20T04:46:42Z
dc.identifier.issn0270-4137
dc.identifier.doi10.1002/pros.20465
dc.identifier.urihttp://hdl.handle.net/10072/22606
dc.description.abstractBACKGROUND. Prostate cancer (PCa) and bone cell interactions are critical in the metastatic phase. Kallikrein 4 (KLK4/hK4) is expressed in both PCa and mineralized tissues. We determined if KLK4/hK4 expression was associated with, and influenced by, the bone environment of metastatic PCa. METHODS. Immunohistochemistry, in vitro co-culture, cell migration, and attachment assays. RESULTS. hK4 was localized to tumor cells and osteoblasts in bone metastases. KLK4/hK4 increased in LNCaP and PC3 cells co-cultured with SaOs2 cells; SaOs2 KLK4/hK4 was unchanged. Co-culture did not affect cell proliferation but altered alkaline phosphatase activity/mRNA levels in SaOs2 cells. KLK4-transfected PC3 cells had increased migration towards SaOs2 conditioned medium and greater attachment to the bone-matrix proteins, collagens I and IV. CONCLUSIONS. hK4 expression and interaction with both tumor cells and osteoblasts suggests a role for hK4 in PCa bone metastasis. Whether this observation is unique to bone metastasis or reflects a role for hK4 in PCa metastasis generally is yet to be established.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Liss,Inc.
dc.publisher.placeUSA
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom348
dc.relation.ispartofpageto360
dc.relation.ispartofissue4
dc.relation.ispartofjournalThe Prostate
dc.relation.ispartofvolume67
dc.rights.retentionY
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchPaediatrics and Reproductive Medicine
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1112
dc.subject.fieldofresearchcode1114
dc.titleKallikrein 4 Is a Potential Mediator of Cellular Interactions Between Cancer Cells and Osteoblasts in Metastatic Prostate Cancer
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2007
gro.hasfulltextNo Full Text
gro.griffith.authorGao, Jin


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