Exercise-related change in airway blood flow in humans: relationship to changes in cardiac output and ventilation
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Author(s)
Morris, Norman R
Ceridon, Maile L
Beck, Kenneth C
Strom, Nicholas A
Schneider, Donald A
Mendes, Eliana S
Wanner, Adam
Johnson, Bruce D
Griffith University Author(s)
Year published
2008
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This study examined the relationship between airway blood flow ( .Q aw), ventilation ( .V E) and cardiac output ( .Q tot) during exercise in healthy humans (n = 12, mean age 34?11 yr). .Q aw was estimated from the uptake of the soluble gas dimethyl ether while .V E and .Q tot were measured using open circuit spirometry. Measurements were made prior to and during exercise at 34?5 W (Load 1) and 68?10 W (Load 2) and following the cessation of exercise (recovery). .Q aw increased in a stepwise fashion (P<0.05) from rest (52.8 ? 19.5 ul?min-1?ml-1) to exercise at Load 1 (67.0 ? 20.3 ul?min-1?ml-1) and Load 2 ...
View more >This study examined the relationship between airway blood flow ( .Q aw), ventilation ( .V E) and cardiac output ( .Q tot) during exercise in healthy humans (n = 12, mean age 34?11 yr). .Q aw was estimated from the uptake of the soluble gas dimethyl ether while .V E and .Q tot were measured using open circuit spirometry. Measurements were made prior to and during exercise at 34?5 W (Load 1) and 68?10 W (Load 2) and following the cessation of exercise (recovery). .Q aw increased in a stepwise fashion (P<0.05) from rest (52.8 ? 19.5 ul?min-1?ml-1) to exercise at Load 1 (67.0 ? 20.3 ul?min-1?ml-1) and Load 2 (84.0 ? 22.9 ul?min-1?ml-1) before returning to pre-exercise levels in recovery (51.7 ? 13.2 ul?min-1?ml-1). .Q aw was positively correlated with both .Q tot (r=0.58, P<0.01) and .V E (r=0.50, P<0.01). These results demonstrate that the increase in .Q aw is linked to an exercise related increase in both .Q tot and .V E and may be necessary to prevent excessive airway cooling and drying
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View more >This study examined the relationship between airway blood flow ( .Q aw), ventilation ( .V E) and cardiac output ( .Q tot) during exercise in healthy humans (n = 12, mean age 34?11 yr). .Q aw was estimated from the uptake of the soluble gas dimethyl ether while .V E and .Q tot were measured using open circuit spirometry. Measurements were made prior to and during exercise at 34?5 W (Load 1) and 68?10 W (Load 2) and following the cessation of exercise (recovery). .Q aw increased in a stepwise fashion (P<0.05) from rest (52.8 ? 19.5 ul?min-1?ml-1) to exercise at Load 1 (67.0 ? 20.3 ul?min-1?ml-1) and Load 2 (84.0 ? 22.9 ul?min-1?ml-1) before returning to pre-exercise levels in recovery (51.7 ? 13.2 ul?min-1?ml-1). .Q aw was positively correlated with both .Q tot (r=0.58, P<0.01) and .V E (r=0.50, P<0.01). These results demonstrate that the increase in .Q aw is linked to an exercise related increase in both .Q tot and .V E and may be necessary to prevent excessive airway cooling and drying
View less >
Journal Title
Respiratory Physiology & Neurobiology
Volume
162
Publisher URI
Copyright Statement
© 2008 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Subject
Cardiovascular medicine and haematology
Neurosciences
Medical physiology
Systems physiology