Medium Ring Ethers by Ring Expansion-Ring Contraction: Synthesis of Lauthisan.
Author(s)
Coster, MJ
De Voss, JJ
Griffith University Author(s)
Year published
2002
Metadata
Show full item recordAbstract
A new general method for the construction of medium ring ethers has been developed. This involves the ring expansion of halo-O,S-acetals followed by a Ramburg-Backlund ring contraction reaction with concomitant extrusion of the sulfur atom. This methodol. has been utilized for the synthesis of racemic cis- and trans-lauthisan (I and II resp.).A new general method for the construction of medium ring ethers has been developed. This involves the ring expansion of halo-O,S-acetals followed by a Ramburg-Backlund ring contraction reaction with concomitant extrusion of the sulfur atom. This methodol. has been utilized for the synthesis of racemic cis- and trans-lauthisan (I and II resp.).
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Journal Title
Organic Letters
Volume
4
Issue
18
Subject
Chemical sciences