Comparative toxicity of the cyanobacterial toxin cylindrospermopsin between mice and cattle: human implications

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Title Comparative toxicity of the cyanobacterial toxin cylindrospermopsin between mice and cattle: human implications
Author Shaw, Glendon Reginald; McKenzie, Ross A.; Wickramasinghe, Wasa A.; Seawright, Alan A.; Eaglesham, Geoff K.; Moore, Michael R.
Publication Title Harmful Algae 2002
Editor Karen A. Steidinger, Jan H. Landsberg, Carmelo R. Tomas, Gabriel A. Vargo
Year Published 2004
Place of publication St. Petersburg, Florida, USA
Publisher Florida Fish and Wildlife Conservation Commission, Florida Institute of Oceanography, and UNESCO
Abstract The cyanobacterial toxin cylindrospermopsin is produced by Cylindrospermopsis raciborskii and Aphanizomenon ovalisporum in many parts of the world. A human poisoning incident occurring at Palm Island, Queensland, Australia in 1979 was subsequently ascribed to cylindrospermopsin. The structure of cylindrospermopsin, a tricyclic guanidinium moiety bridged to hydroxymethyluracil, was deduced in 1992. A number of studies have investigated the acute toxicity of cylindrospermopsin in mice. It is primarily a hepatotoxin with a 24-hour acute intraperitoneal (IP) LD50 of 2 mg/kg, a 5-day acute i.p. LD50 of 0.2 mg/kg and a 5-day acute oral LD50 of approximately 6 mg/kg. A human health risk assessment using data from longer-term oral dosing studies suggests a guideline value for cylindrospermopsin in drinking water of approximately 10 μg/L.We have recently studied cattle poisonings by cylindrospermopsin and detected the toxin in a number of tissues after necropsy. Concentrations of 1 mg/L or above in drinking water (dose is approximately 50 μg/kg/day) were shown to result in cattle death after short-term exposure (less than 10 days). Oral dosing of mice at levels up to 5 mg/L with cylindrospermopsin in drinking water for 90 days did not produce any significant toxicity. Human health risk assessment based on cattle however, which are much more sensitive to cylindrospermopsin than rodents, would produce a guideline for human drinking water of approximately 0.05 μg/L. A consideration of reported human poisoning incidents that implicate cylindrospermopsin suggests that humans may also be more sensitive than rodents to this toxin.
Peer Reviewed Yes
Published Yes
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Copyright Statement Copyright 2002 ISSH. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the conference's website for access to the definitive, published version.
Conference name Xth International Conference on Harmful Algae
Location St. Pete Beach, Florida, USA
Date From 2002-10-21
Date To 2002-10-25
Date Accessioned 2006-07-24
Language en_US
Faculty Griffith Health Faculty
Subject PRE2009-Environmental and Occupational Health and Safety
WWW reference
Publication Type Conference Publications (Full Written Paper - Refereed)
Publication Type Code e1x

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