Functional differences between M cells and enterocytes in sampling luminal antigens

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Title Functional differences between M cells and enterocytes in sampling luminal antigens
Author Kyd, Jennelle M.; Cripps, Allan W
Journal Name Vaccine
Editor Dr. R E Spier
Year Published 2008
Place of publication United Kingdom
Publisher Elsevier Ltd.
Abstract Oral delivery of agents such as vaccines offers a number of significant advantages over parenteral routes, yet only a small number of oral vaccines are routinely available today. The small intestine contains lymphoid aggregates that are overlaid by M cells. These aggregates are part of the gut-associated lymphoid tissues and are important for determining host responses to particulate antigenic material within the small intestine. Differentiating the receptor requirements for M cell uptake and transcytosis of bacterial antigen from the intestine has progressed although the specific signalling mechanisms that initiate antigen uptake and specifically target antigen to these cells is still relatively unknown. Microbial pathogen-associated molecular patterns (PAMPs) are recognised by the innate immune system through pattern recognition receptors (PRRs) either through direct receptor-bacterial ligand or endogenous adaptor-bacterial molecule interactions. PRRs on the surface of M cells that have been identified as important in antigen transcytosis include toll-like receptor-4, platelet-activating factor receptor and α5β1 integrin. A number of these PRRs are also found on neighbouring enterocytes and therefore the pathways signalled by receptor-ligand binding may differentially trigger different transduction pathways. Elucidation of these signalling pathways may assist in the design of effective oral vaccines that target the gut-associated lymphoid tissue.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.vaccine.2008.09.061
Copyright Statement Copyright 2008 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Volume 26
Issue Number 49
Page from 6221
Page to 6224
ISSN 0264-410X
Date Accessioned 2009-04-29
Language en_AU
Research Centre Griffith Health Institute; Molecular Basis of Disease
Faculty Griffith Health Faculty
Subject Immunology
URI http://hdl.handle.net/10072/23279
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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