Show simple item record

dc.contributor.authorFernandez, Francesca
dc.contributor.authorEsposito, Teresa
dc.contributor.authorLea, Rod A
dc.contributor.authorColson, Natalie J
dc.contributor.authorCiccodicola, Alfredo
dc.contributor.authorGianfrancesco, Fernando
dc.contributor.authorGriffiths, Lyn R
dc.date.accessioned2017-05-03T14:06:08Z
dc.date.available2017-05-03T14:06:08Z
dc.date.issued2008
dc.date.modified2009-05-15T09:08:04Z
dc.identifier.issn1471-2350
dc.identifier.doi10.1186/1471-2350-9-109
dc.identifier.urihttp://hdl.handle.net/10072/23346
dc.description.abstractBackground: Migraine is a neurological disorder characterized by recurrent attacks of severe headache, affecting around 12% of Caucasian populations. It is well known that migraine has a strong genetic component, although the number and type of genes involved is still unclear. Prior linkage studies have reported mapping of a migraine gene to chromosome Xq 24-28, a region containing a cluster of genes for GABA A receptors (GABRE, GABRA3, GABRQ), which are potential candidate genes for migraine. The GABA neurotransmitter has been implicated in migraine pathophysiology previously; however its exact role has not yet been established, although GABA receptors agonists have been the target of therapeutic developments. The aim of the present research is to investigate the role of the potential candidate genes reported on chromosome Xq 24-28 region in migraine susceptibility. In this study, we have focused on the subunit GABA A receptors type e (GABRE) and type ? (GABRQ) genes and their involvement in migraine. Methods: We have performed an association analysis in a large population of case-controls (275 unrelated Caucasian migraineurs versus 275 controls) examining a set of 3 single nucleotide polymorphisms (SNPs) in the coding region (exons 3, 5 and 9) of the GABRE gene and also the I478F coding variant of the GABRQ gene. Results: Our study did not show any association between the examined SNPs in our test population (P > 0.05). Conclusion: Although these particular GABA receptor genes did not show positive association, further studies are necessary to consider the role of other GABA receptor genes in migraine susceptibility.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent377549 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherBioMed Central Ltd.
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto10
dc.relation.ispartofissue109
dc.relation.ispartofjournalBMC Medical Genetics
dc.relation.ispartofvolume9
dc.rights.retentionY
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchNeurogenetics
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3105
dc.subject.fieldofresearchcode310511
dc.subject.fieldofresearchcode3202
dc.titleInvestigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/2.0
gro.facultyGriffith Health, School of Medical Science
gro.rights.copyright© 2008 Fernandez, et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.date.issued2008
gro.hasfulltextFull Text
gro.griffith.authorColson, Natalie J.


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record