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dc.contributor.authorVanderlelie, J
dc.contributor.authorGude, N
dc.contributor.authorPerkins, AV
dc.date.accessioned2017-05-03T11:16:53Z
dc.date.available2017-05-03T11:16:53Z
dc.date.issued2008
dc.date.modified2009-09-17T07:23:07Z
dc.identifier.issn0143-4004
dc.identifier.doi10.1016/j.placenta.2008.02.016
dc.identifier.urihttp://hdl.handle.net/10072/23374
dc.description.abstractOxidative stress has been implicated in the pathogenesis of preeclampsia. This study measured the relative mRNA expression of antioxidant proteins glutathione peroxidase 1 and 4, glutathione reductase, thioredoxin 1 and 2, thioredoxin reductase 1, thioredoxin peroxidase 3 and superoxide dismutase 1 and 2 in preeclamptic and non-preeclamptic placentae. Quantitative real-time PCR was conducted on placental mRNA isolated from preeclamptic and control patients. Cycle threshold numbers and fold differences were calculated as a measure of linear product amplification and used for comparison. The mRNA expression of glutathione reductase was significantly reduced (fold difference 0.41, p<0.05) in preeclamptic placenta when compared to controls while the expression of thioredoxin peroxidase 3 was significantly increased (fold difference 3.25, p<0.001) in the preeclamptic placentae. No significant difference in expression was observed for glutathione peroxidase 1 and 4, thioredoxin 1 and 2, thioredoxin reductase 1 and superoxide dismutase 1 and 2. These results suggest that it is the abnormal oxidative insult associated with preeclampsia not mRNA expression of antioxidant proteins that may be responsible for reduced antioxidant enzyme activity in preeclamptic placentae.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeHolland
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom519
dc.relation.ispartofpageto522
dc.relation.ispartofissue6
dc.relation.ispartofjournalPlacenta
dc.relation.ispartofvolume29
dc.rights.retentionY
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3202
dc.titleAntioxidant Gene Expression in Preeclamptic Placentae: A Preliminary Investigation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.date.issued2008
gro.hasfulltextNo Full Text
gro.griffith.authorPerkins, Anthony V.
gro.griffith.authorVanderlelie, Jessica J.


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