A systematic review of the literature of the effects of laser irradiation on peripheral mammalian nerves: Relevance to the pain relieving effects of Low-Level Laser Therapy

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Title A systematic review of the literature of the effects of laser irradiation on peripheral mammalian nerves: Relevance to the pain relieving effects of Low-Level Laser Therapy
Author Chow, R.; Laakso, Liisa; Armati, P.J.; Baxter, G.D.
Publication Title The World Association of Laser Therapy: WALT South Africa 2008
Year Published 2008
Abstract Background: Low-Level Laser Therapy (LLLT) is increasingly used in the treatment of acute and chronic pain. Strong evidence from several systematic reviews and randomised controlled trials supports the efficacy of LLLT in neck pain, tendinitis and osteoarthritis and other painful conditions. Neural inhibition has been proposed as a mechanism for LLLT efficacy in pain relief. We therefore undertook a review of the literature to identify the effects of laser irradiation (LI) on electrophysiology and morphology of peripheral nerves and how such effects modulate pain. Methods: We searched computerised databases, reference lists and cosulted relevant experts. Using a priori inclusion and exclusion criteria we identified 38 relevant studies encompassing 82 experiments. Results: In human studies pulsed and continuous visible and continuous wave (cw) infrared LI slowed conduction velocity (CV) and reduced the amplitude of compound action potentials (CAPs). In animal experiments infrared LI suppressed CV and electrically and noxiously evoked action potentials including response to inflammatory mediators. Specifically, 830nm, cw, LI inhibited fast axonal flow, and decreased both mitochondrial membrane potential and ATP within axons. Conclusion: This review identifies laser-induced inhibitory effects in a diverse range of human and animal peripheral nerve models. Such effects provide a mechanism for reduction of acute pain by direct inhibition of A-delta and C fibres. In chronic pain, we propose that spinal cord changes induced by LI in the periphery can induce long-term depression of pain via central neuroplasticity resulting in clinical pain relief.
Peer Reviewed No
Published Yes
Publisher URI http://www.walt.nu/
Alternative URI http://www.medimond.com/proceedings/detail.asp?id=20081019
Copyright Statement Copyright 2008 MEDIMOND. For information about this conference please refer to the publisher's website.
Conference name WALT South Africa 2008
Location Sun City South Africa
Date From 2008-10-19
Date To 2008-10-22
URI http://hdl.handle.net/10072/25064
Date Accessioned 2009-01-19
Date Available 2009-08-10T06:27:21Z
Language en_AU
Research Centre Griffith Health Institute; Centre for Musculoskeletal Research
Faculty Griffith Health Faculty
Subject Complementary and Alternative Medicine
Publication Type Conference Publications (Extract Paper)
Publication Type Code e3

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