Progress in Proneurotrophins Functions
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Author(s)
Fan, Yong-Jun
Xu, Jian
Griffith University Author(s)
Year published
2008
Metadata
Show full item recordAbstract
Neurotrophins are a group of structurally related polypeptide that provides trophic support for different neuronal subpopulation in the developing and adult nervous system, contributing to the development, maintenance and function of central nervous system and peripheral nervous system. Functional mature neurotrophins were released from their precusors (proneurotrophins) by proteolysis intracellularly or extracellularly. Recent studies show that the proneurotrophins have antagonistic functions with their mature counterparts, in most cases, inducing neuronal apoptosis by p75^[NTR]/sortilin receptor complex rather than surviving ...
View more >Neurotrophins are a group of structurally related polypeptide that provides trophic support for different neuronal subpopulation in the developing and adult nervous system, contributing to the development, maintenance and function of central nervous system and peripheral nervous system. Functional mature neurotrophins were released from their precusors (proneurotrophins) by proteolysis intracellularly or extracellularly. Recent studies show that the proneurotrophins have antagonistic functions with their mature counterparts, in most cases, inducing neuronal apoptosis by p75^[NTR]/sortilin receptor complex rather than surviving neuronal cells by trophic effect. These results suggested that the proneurotrophins may contribute to adjusting the ratio of neuronal subpopulations in development and inducing neuron death in degeneration or in response to injury in adult. The accumulating data will be helpful to understand the exactly role or pathological mechanism of proneurotrophins in nerve system and may supply new means to develop new drugs for clinical therapy.
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View more >Neurotrophins are a group of structurally related polypeptide that provides trophic support for different neuronal subpopulation in the developing and adult nervous system, contributing to the development, maintenance and function of central nervous system and peripheral nervous system. Functional mature neurotrophins were released from their precusors (proneurotrophins) by proteolysis intracellularly or extracellularly. Recent studies show that the proneurotrophins have antagonistic functions with their mature counterparts, in most cases, inducing neuronal apoptosis by p75^[NTR]/sortilin receptor complex rather than surviving neuronal cells by trophic effect. These results suggested that the proneurotrophins may contribute to adjusting the ratio of neuronal subpopulations in development and inducing neuron death in degeneration or in response to injury in adult. The accumulating data will be helpful to understand the exactly role or pathological mechanism of proneurotrophins in nerve system and may supply new means to develop new drugs for clinical therapy.
View less >
Journal Title
Chinese Journal of Cell Biology
Volume
30
Issue
4
Publisher URI
Copyright Statement
© The Author(s) 2008. The attached file is reproduced here in accordance with the copyright policy of the publisher. For information about this journal please refer to the journal’s website or contact the authors.
Subject
Biochemistry and Cell Biology not elsewhere classified