FGF2 Promotes Neuronal Differentiation in Explant Cultures of Adult and Embryonic Mouse Olfactory Epithelium

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Title FGF2 Promotes Neuronal Differentiation in Explant Cultures of Adult and Embryonic Mouse Olfactory Epithelium
Author MacDonald, Kelli Patricia; Murrell, Wayne George; Mackay-Sim, Alan; Bushell, Gillian Robin; Bartlett, P.F.
Journal Name Journal of Neuroscience Research
Year Published 1996
Place of publication USA
Publisher John Wiley & Sons
Abstract Neurogenesis in the adult olfactory epithelium is highly regulated in vivo. Little is known of the molecular signals which control this process, although contact with the olfactory bulb or with astrocytes has been implicated. Explants of mouse olfactory epithelium were grown in the presence or absence of several peptide growth factors. Basic fibroblast growth factor (FGF2) stimulated differentiation of sensory neurons in adult and embryonic olfactory epithelium. Other growth factors tested were ineffective. FGF2-stimulated neurons were born in vitro and expressed neurofilament, neural cell adhesion molecule, and -tubulin. The cells also expressed olfactory marker protein, a marker for mature olfactory sensory neurons in vivo. These bipolar neurons did not express glial fibrillary acidic protein or low-affinity nerve growth factor receptor. These results indicate that neither astrocytes nor olfactory bulb are necessary for differentiation of olfactory sensory neurons in vitro. © 1996 Wiley-Liss, Inc.
Peer Reviewed Yes
Published Yes
Publisher URI http://www3.interscience.wiley.com/journal/34828/home
Alternative URI http://dx.doi.org/10.1002/(SICI)1097-4547(19960401)44:1<27::AID-JNR4>3.0.CO;2-K
Copyright Statement Copyright 1996 John Wiley & Sons, Ltd. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the author for more information.
Volume 44
Page from 27
Page to 39
ISSN 0360-4012
Date Accessioned 1997-01-01
Date Available 2009-09-21T05:47:40Z
Language en_AU
Research Centre Eskitis Institute for Drug Discovery; Griffith Medical Research College
URI http://hdl.handle.net/10072/25723
Publication Type Article in Scholarly Refereed Journal
Publication Type Code c1

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