Dopamine Promotes differentiation of Olfactory neuron in vitro

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Title Dopamine Promotes differentiation of Olfactory neuron in vitro
Author Feron, Francois; Vincent, Adele Joan; Mackay-Sim, Alan
Journal Name Brain Research
Year Published 1999
Place of publication Netherlands
Publisher Elsevier Science
Abstract In two previous in vitro experiments, we have shown that dopamine induced apoptosis or differentiation in an olfactory cell line while it reduced mitosis and triggered cell death in human olfactory biopsy cultures. The aims of the present study were to locate precisely D2 dopamine receptors within the olfactory epithelium and to monitor the effect of dopamine on olfactory neuronal differentiation in explant cultures. We show here that D2 dopamine receptors are expressed in supporting cells, neurons and basal cells in the olfactory epithelium. In vitro, dopamine was found to (1) trigger neuronal differentiation and maturation in a dose-dependent manner via D2 dopamine receptors, (2) be active only when not oxidised, (3) act directly on epithelial cells and not through other reactive cells in the underlying lamina propria. Altogether these data indicate that, in parallel to its action in odour processing, dopamine plays a growth factor-like role in the permanent neurogenesis observed in the olfactory epithelium.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.sciencedirect.com/science/journal/00068993
Alternative URI http://dx.doi.org/10.1016/S0006-8993(99)01959-9
Volume 845
Page from 252
Page to 259
ISSN 0006-8993
Date Accessioned 2000-01-01
Date Available 2009-09-22T05:51:34Z
Language en_AU
Research Centre Eskitis Institute for Drug Discovery
URI http://hdl.handle.net/10072/25754
Publication Type Article in Scholarly Refereed Journal
Publication Type Code c1

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