Neurogenesis in Adult Human

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Title Neurogenesis in Adult Human
Author Murrell, Wayne; Bushell, Gillian; Mackay-Sim, Alan; Bates, Paul; MacDonald, Kelli P.; Livesey, Jonathon; McGrath, John
Journal Name Developmental Neuroscience
Year Published 1996
Place of publication USA
Publisher S. Karger
Abstract THIS report describes neurogenesis in the adult human olfactory epithelium in vitro. Olfactory epithelium was collected at autopsy and by biopsy, and grown in serum-free medium. Basic fibroblast growth factor induced the differentiation of bipolar cells which were immunopositive for several neuronal proteins but not glial proteins. [3H]thymidine autoradiography confirmed that these neurones were born in vitro. The results demonstrate that the adult human olfactory epithelium retains the capacity for neurogenesis and neuronal differentiation, at least until the age of 72 years. It is now possible to examine neurones and neurogenesis in biopsies from patients with disorders that may involve a neurodevelopmental or neurodegenerative aetiology such as schizophrenia, bipolar disorder and Alzheimer's disease.
Peer Reviewed Yes
Published Yes
Publisher URI http://journals.lww.com/neuroreport/pages/default.aspx
Alternative URI http://www.ncbi.nlm.nih.gov/pubmed/8817530
Volume 7
Issue Number 6
Page from 1189
Page to 1194
ISSN 0959-4965
Date Accessioned 1997-01-01
Date Available 2009-09-22T05:52:20Z
Language en_AU
Research Centre Eskitis Institute for Drug Discovery; Griffith Medical Research College
Faculty Faculty of Science, Environment, Engineering and Technology
URI http://hdl.handle.net/10072/25758
Publication Type Article in Scholarly Refereed Journal
Publication Type Code c1

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