G-CSF Immunotherapy for Treatment of Acute Disseminated Murine Melioidosis

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Title G-CSF Immunotherapy for Treatment of Acute Disseminated Murine Melioidosis
Author Powell, Kellie; Ulett, Glen Charles; Hirst, Robert; Norton, Robert
Journal Name FEMS Microbiology Letters
Year Published 2003
Place of publication The Netherlands
Publisher Blackwell Publishing Ltd
Abstract Burkholderia pseudomallei, the causative agent of melioidosis, is an important pathogen in tropical regions of Australia and Southeast Asia. Antibiotic therapy can be ineffective in patients with acute septicaemic melioidosis. It has been proposed that adjunctive immunotherapy using granulocyte colony stimulating factor (G-CSF) combined with antibiotics may provide an alternative approach to antibiotics alone. We have developed a murine model for melioidosis that allows novel treatment approaches to be investigated. This study looked at the potential for murine G-CSF therapy both alone and as an adjunct in the treatment of acute disseminated B. pseudomallei infection in BALB/c mice. A number of therapeutic variables involving ceftazidime and recombinant murine G-CSF were studied. Surviving mice were sacrificed and splenic bacterial loads were determined. Combining recombinant murine G-CSF with ceftazidime offered no advantage over ceftazidime alone. Pre-treatment with recombinant murine G-CSF did not demonstrate a significant benefit. This would suggest that adjunct immunotherapy using G-CSF is of limited benefit.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.sciencedirect.com/science/journal/03781097
Alternative URI http://dx.doi.org/10.1016/S0378-1097(03)00473-7
Copyright Statement Copyright 2003 Wiley-Blackwell Publishing. The definitive version is available at www.interscience.wiley.com This is the author-manuscript version of the paper. Reproduced in accordance with the copyright policy of the publisher.
Volume 224
Issue Number 2
Page from 315
Page to 318
ISSN 0378-1097
Date Accessioned 2009-02-20
Language en_AU
Research Centre Menzies Health Institute Qld; Molecular Basis of Disease
Faculty Griffith Health Faculty
Subject Medical Bacteriology
URI http://hdl.handle.net/10072/25845
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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