The multicopper oxidase (CueO) and cell aggregation in Escherichia coli
Author(s)
Tree, Jai J
Ulett, Glenn C
Hobman, Jon L
Constantinidou, Chrystala
Brown, Nigel L
Kershaw, Christopher
Schembri, Mark A
Jennings, Michael P
McEwan, Alastair G
Year published
2007
Metadata
Show full item recordAbstract
cueO encodes a periplasmic multicopper oxidase, which is known to be involved in copper homeostasis and protection against oxidative stress in Escherichia coli K12. Transcriptional profiling showed that expression of genes associated with motility was lowered in a cueO mutant while expression of genes associated with autoaggregation was elevated. Increased aggregation was correlated with increased expression of cell surface proteins antigen 43 and curli. Changes in gene expression caused by the deletion of cueO were essentially independent of SoxR and OxyR, the global regulators of oxidative stress response.cueO encodes a periplasmic multicopper oxidase, which is known to be involved in copper homeostasis and protection against oxidative stress in Escherichia coli K12. Transcriptional profiling showed that expression of genes associated with motility was lowered in a cueO mutant while expression of genes associated with autoaggregation was elevated. Increased aggregation was correlated with increased expression of cell surface proteins antigen 43 and curli. Changes in gene expression caused by the deletion of cueO were essentially independent of SoxR and OxyR, the global regulators of oxidative stress response.
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Journal Title
Environmental Microbiology
Volume
9
Issue
8
Subject
Evolutionary biology
Microbiology
Medical bacteriology
Ecology