Effects of sprint training on extrarenal potassium regulation with intense exercise in Type I diabetes

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Title Effects of sprint training on extrarenal potassium regulation with intense exercise in Type I diabetes
Author Harmer, Alison R.; Ruell, Patricia A.; McKenna, Michael J.; Chisholm, Donald J.; Hunter, Sandra K.; Thom, Jeanette M.; Morris, Norman; Flack, Jeff R.
Journal Name Journal of Applied Physiology
Year Published 2006
Place of publication Bethesda, MD
Publisher American Physiological Society
Abstract Effects of sprint training on plasma K+ concentration ([K+]) regulation during intense exercise and on muscle Na+-K+-ATPase were investigated in subjects with Type 1 diabetes mellitus (T1D) under real-life conditions and in nondiabetic subjects (CON). Eight subjects with T1D and seven CON undertook 7 wk of sprint cycling training. Before training, subjects cycled to exhaustion at 130% peak O2 uptake. After training, identical work was performed. Arterialized venous blood was drawn at rest, during exercise, and at recovery and analyzed for plasma glucose, [K+], Na+ concentration ([Na+]), catecholamines, insulin, and glucagon. A vastus lateralis biopsy was obtained before and after training and assayed for Na+-K+-ATPase content ([3H]ouabain binding). Pretraining, Na+-K+-ATPase content and the rise in plasma [K+] ([K+]) during maximal exercise were similar in T1D and CON. However, after 60 min of recovery in T1D, plasma [K+], glucose, and glucagon/insulin were higher and plasma [Na+] was lower than in CON. Training increased Na+-K+-ATPase content and reduced [K+] in both groups (P < 0.05). These variables were correlated in CON (r = –0.65, P < 0.05) but not in T1D. This study showed first that mildly hypoinsulinemic subjects with T1D can safely undertake intense exercise with respect to K+ regulation; however, elevated [K+] will ensue in recovery unless insulin is administered. Second, sprint training improved K+ regulation during intense exercise in both T1D and CON groups; however, the lack of correlation between plasma [K+] and Na+-K+-ATPase content in T1D may indicate different relative contributions of K+-regulatory mechanisms.
Peer Reviewed Yes
Published Yes
Publisher URI http://jap.physiology.org/
Alternative URI http://dx.doi.org/10.1152/japplphysiol.00240.2005
Volume 100
Page from 26
Page to 34
ISSN 8750-7587
Date Accessioned 2007-04-19
Language en_AU
Research Centre Menzies Health Institute Qld; Heart Foundation Research Centre
Faculty Griffith Health Faculty
Subject PRE2009-Exercise Physiology; PRE2009-Systems Physiology
URI http://hdl.handle.net/10072/26048
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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