Cytokine gene polymorphisms in preterm infants with necrotising enterocolitis: genetic association study

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Title Cytokine gene polymorphisms in preterm infants with necrotising enterocolitis: genetic association study
Author Henderson, Ginny; Craig, S; Baier, RJ; Helps, N; Brocklehurst, P; McGuire, M
Journal Name Archives of Disease in Childhood - Fetal and Neonatal Edition
Year Published 2009
Place of publication London
Publisher BMJ Publishinhg Group Ltd
Abstract Background: The inflammatory cytokine cascade is implicated in the pathogenesis of necrotising enterocolitis (NEC). Genetic association studies of cytokine polymorphisms may help to detect molecular mechanisms that are causally related to the disease process.Aim: To examine associations between the common genetic variants in candidate inflammatory cytokine genes and NEC in preterm infants.Methods: Multi-centre case-control and genetic association study. We collected DNA samples from 50 preterm infants with NEC and 50 gestational age and ethnic group frequency-matched controls recruited to a multi-centre case-control study. We genotyped 10 candidate single nucleotide polymorphisms (SNPs) in cytokines previously associated with infectious or inflammatory diseases in preterm infants. The findings were included in random effects meta-analyses with data from previous genetic association studies.Results: All allele distributions were in Hardy-Weinberg equilibrium. None of the studied cytokine polymorphisms was significantly associated with NEC. We found four previous genetic association studies of cytokine polymorphisms and NEC in preterm infants. Meta-analyses were possible for several SNPs. These increased the precision of the estimates of effect size but did not reveal any significant associations.Conclusions: The available data are not consistent with more than modest associations between these candidate cytokine variant alleles and NEC in preterm infants. Data from future association studies of these polymorphisms may be added to the meta-analyses to obtain more precise estimates of effects sizes.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.bmj.com/
Alternative URI http://dx.doi.org/10.1136/adc.2007.119933
Copyright Statement Copyright remains with the authors 2009 . This attached file is posted here with permission of the copyright owner for your personal use only. No further distribution permitted. For information about this journal please refer to the publisher's website or contact the authors.
Volume 94
Page from F124
Page to F128
ISSN 1359-2998
Date Accessioned 2007-10-26
Date Available 2010-01-12T06:54:32Z
Language en_AU
Faculty Griffith Health Faculty
Subject PRE2009-Nursing
URI http://hdl.handle.net/10072/26065
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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