Aberrant trafficking of transmembrane proteins in human disease
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| Title | Aberrant trafficking of transmembrane proteins in human disease |
|---|---|
| Author | Cobbold, Christian; Monaco, Anthony P.; Sivaprasadarao, Asipu; Ponnambalam, Sreenivasan |
| Journal Name | Trends in Cell Biology |
| Year Published | 2003 |
| Place of publication | United Kingdom |
| Publisher | Elsevier |
| Abstract | Transmembrane domain (TMD) proteins comprise a major group of proteins that perform a wide range of functions and act to translate extracellular signals to intracellular responses. They include G-protein coupled receptors (GPCRs), growth factor receptors, ion channels, transporters and metabolic enzymes. In this review, we focus on the current understanding of trafficking of mutant membrane proteins in human disease and speculate on therapeutic strategies. |
| Peer Reviewed | Yes |
| Published | Yes |
| Publisher URI | http://www.cell.com/trends/cell-biology/home |
| Alternative URI | http://dx.doi.org/10.1016/j.tcb.2003.10.008 |
| Volume | 13 |
| Issue Number | 12 |
| Page from | 639 |
| Page to | 647 |
| ISSN | 0962-8924 |
| Date Accessioned | 2006-06-28 |
| Date Available | 2009-12-22T03:06:38Z |
| Language | en_AU |
| Faculty | Faculty of Science |
| Subject | PRE2009-Protein Targeting and Signal Transduction |
| URI | http://hdl.handle.net/10072/26481 |
| Publication Type | Journal Articles (Refereed Article) |
| Publication Type Code | c1x |
Please use this identifier to cite this record: http://hdl.handle.net/10072/26481
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