Aberrant trafficking of transmembrane proteins in human disease

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Title Aberrant trafficking of transmembrane proteins in human disease
Author Cobbold, Christian; Monaco, Anthony P.; Sivaprasadarao, Asipu; Ponnambalam, Sreenivasan
Journal Name Trends in Cell Biology
Year Published 2003
Place of publication United Kingdom
Publisher Elsevier
Abstract Transmembrane domain (TMD) proteins comprise a major group of proteins that perform a wide range of functions and act to translate extracellular signals to intracellular responses. They include G-protein coupled receptors (GPCRs), growth factor receptors, ion channels, transporters and metabolic enzymes. In this review, we focus on the current understanding of trafficking of mutant membrane proteins in human disease and speculate on therapeutic strategies.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.cell.com/trends/cell-biology/home
Alternative URI http://dx.doi.org/10.1016/j.tcb.2003.10.008
Volume 13
Issue Number 12
Page from 639
Page to 647
ISSN 0962-8924
Date Accessioned 2006-06-28
Language en_AU
Faculty Faculty of Science
Subject PRE2009-Protein Targeting and Signal Transduction
URI http://hdl.handle.net/10072/26481
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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