Myocardial susceptibility to ischemic-reperfusion injury in a prediabetic model of dietary-induced obesity

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Title Myocardial susceptibility to ischemic-reperfusion injury in a prediabetic model of dietary-induced obesity
Author Du Toit, Eugene; Smith, Wayne; Muller, Christo; Strijdom, Hans; Stouthammer, Bernadette; Woodiwiss, Angela J.; Norton, Gavin R.; Lochner, Amanda
Journal Name American Journal of Physiology
Year Published 2008
Place of publication Bethesda, USA.
Publisher American Physiological Society
Abstract We assessed the myocardial susceptibility to ischemic-reperfusion injury in obese rat hearts in the absence and the presence of predicted circulating concentrations of insulin and fatty acids. Feeding rats a high-calorie diet resulted in increases in body weight, visceral fat content, cardiac hypertrophy, plasma insulin, nonesterified free fatty acid, and triglyceride concentrations. In the absence of both insulin and fatty acids in the coronary perfusate, the hearts of obese rats developed an increased infarct size (41.9 ± 1.9% for obese vs. 22.9 ± 2.3% for control, P < 0.05) and a reduced percent recovery of aortic output (4.2 ± 4.2% for obese vs. 27.7 ± 3.4% for controls, P < 0.05) after coronary artery occlusion and reperfusion. In the presence of insulin in the coronary perfusate, a cardioprotective effect was noted in both groups, an action that was greater in hearts from obese compared with control rats and which abolished the obesity-induced changes in infarct size (13.8 ± 1.2% for controls vs. 21.0 ± 1.6% for obese), and percent recovery of aortic output (60.2 ± 4.7% for controls vs. 45.7 ± 9.4% for obese). Fatty acids (0.7 mM, control; and 1.5 mM, obese) added to the coronary perfusate with in vivo concentrations of insulin dramatically increased infarct size (48.2 ± 3.1% for obese, and 37.5 ± 2.7% for control; P < 0.05 vs. without fatty acids) and decreased percent aortic output recovery (control, 10.4 ± 5.2%, and obese 7.8 ± 3.5%; P < 0.05 vs. without fatty acids) in both groups to similar values. In conclusion, in obesity, the impact of an increased susceptibility of the myocardium to ischemic-reperfusion injury on myocardial injury is likely to be overshadowed by the comparatively greater roles played by predicted increases in circulating insulin and fatty acids found in vivo. These data support the notion that adiposity per se is unlikely to be a valuable predictor of outcomes in ischemic-reperfusion injury.
Peer Reviewed Yes
Published Yes
Publisher URI http://ajpcon.physiology.org/
Alternative URI http://dx.doi.org/10.1152/ajpheart.00481.2007
Copyright Statement Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
Volume 294
Page from H2336
Page to H2343
ISSN 0363-6135
Date Accessioned 2009-06-29
Language en_AU
Research Centre Griffith Health Institute
Faculty Griffith Health Faculty
Subject Cardiology (incl Cardiovascular Diseases)
URI http://hdl.handle.net/10072/26729
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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