dc.contributor.author | Hamlet, SM | |
dc.contributor.author | Ganashan, N | |
dc.contributor.author | Cullinan, MP | |
dc.contributor.author | Westerman, B | |
dc.contributor.author | Palmer, JE | |
dc.contributor.author | Seymour, GJ | |
dc.contributor.editor | Robert Genco (Editor-in-Chief), Julie Daw (Managing Editor) | |
dc.date.accessioned | 2017-05-03T16:56:24Z | |
dc.date.available | 2017-05-03T16:56:24Z | |
dc.date.issued | 2008 | |
dc.date.modified | 2013-05-28T23:04:18Z | |
dc.identifier.issn | 0022-3492 | |
dc.identifier.doi | 10.1902/jop.2008.070228 | |
dc.identifier.uri | http://hdl.handle.net/10072/26746 | |
dc.description.abstract | Background: Tannerella forsythia (previously T. forsythensis) in subgingival plaque has been recognized as a defined periodontal pathogen, but its mere presence may be insufficient for disease initiation and/or progression. The organism may produce a cysteine protease, encoded by the prtH gene, which may play a role in the transition from commensal organism to opportunistic pathogen. This study aimed to relate changes in the level of 7. forsythia prtH genotype over a 5-year period to a concomitant loss of attachment. Methods: Real-time polymerase chain reaction was used to quantify the level of the prtH gene in plaque samples from subjects with and without attachment loss (>2 mm in at least two sites) over a 5-year period. Clinical measures and subgingival plaque samples were obtained at yearly intervals. Results: Baseline levels of the prtH genotype were significantly lower in the subjects without loss of attachment compared to those who lost attachment over 1, 2, 4, or 5 years. In the subjects with loss of attachment, the higher prtH levels at baseline were not maintained until the end of the observation period. Conclusion: Higher levels of the prtH genotype were associated significantly with future attachment loss. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | American Academy of Periodontology | |
dc.publisher.place | United States | |
dc.publisher.uri | http://www.joponline.org/ | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 144 | |
dc.relation.ispartofpageto | 149 | |
dc.relation.ispartofissue | 1 | |
dc.relation.ispartofjournal | Journal of Periodontology | |
dc.relation.ispartofvolume | 79 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Dentistry | |
dc.subject.fieldofresearch | Dentistry not elsewhere classified | |
dc.subject.fieldofresearchcode | 3203 | |
dc.subject.fieldofresearchcode | 320399 | |
dc.title | A 5-year longitudinal study of tannerella forsythia prtH genotype: Association with loss of attachment | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.faculty | Griffith Health, School of Dentistry and Oral Health | |
gro.rights.copyright | Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information. | |
gro.date.issued | 2008 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Hamlet, Stephen | |