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dc.contributor.authorHamlet, SM
dc.contributor.authorGanashan, N
dc.contributor.authorCullinan, MP
dc.contributor.authorWesterman, B
dc.contributor.authorPalmer, JE
dc.contributor.authorSeymour, GJ
dc.contributor.editorRobert Genco (Editor-in-Chief), Julie Daw (Managing Editor)
dc.date.accessioned2017-05-03T16:56:24Z
dc.date.available2017-05-03T16:56:24Z
dc.date.issued2008
dc.date.modified2013-05-28T23:04:18Z
dc.identifier.issn0022-3492
dc.identifier.doi10.1902/jop.2008.070228
dc.identifier.urihttp://hdl.handle.net/10072/26746
dc.description.abstractBackground: Tannerella forsythia (previously T. forsythensis) in subgingival plaque has been recognized as a defined periodontal pathogen, but its mere presence may be insufficient for disease initiation and/or progression. The organism may produce a cysteine protease, encoded by the prtH gene, which may play a role in the transition from commensal organism to opportunistic pathogen. This study aimed to relate changes in the level of 7. forsythia prtH genotype over a 5-year period to a concomitant loss of attachment. Methods: Real-time polymerase chain reaction was used to quantify the level of the prtH gene in plaque samples from subjects with and without attachment loss (>2 mm in at least two sites) over a 5-year period. Clinical measures and subgingival plaque samples were obtained at yearly intervals. Results: Baseline levels of the prtH genotype were significantly lower in the subjects without loss of attachment compared to those who lost attachment over 1, 2, 4, or 5 years. In the subjects with loss of attachment, the higher prtH levels at baseline were not maintained until the end of the observation period. Conclusion: Higher levels of the prtH genotype were associated significantly with future attachment loss.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Academy of Periodontology
dc.publisher.placeUnited States
dc.publisher.urihttp://www.joponline.org/
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom144
dc.relation.ispartofpageto149
dc.relation.ispartofissue1
dc.relation.ispartofjournalJournal of Periodontology
dc.relation.ispartofvolume79
dc.rights.retentionY
dc.subject.fieldofresearchDentistry
dc.subject.fieldofresearchDentistry not elsewhere classified
dc.subject.fieldofresearchcode3203
dc.subject.fieldofresearchcode320399
dc.titleA 5-year longitudinal study of tannerella forsythia prtH genotype: Association with loss of attachment
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Dentistry and Oral Health
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
gro.date.issued2008
gro.hasfulltextNo Full Text
gro.griffith.authorHamlet, Stephen


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