A randomised controlled study of the efficacy of hypromellose and Lacri-Lube combination versus polyethylene/Cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient

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Title A randomised controlled study of the efficacy of hypromellose and Lacri-Lube combination versus polyethylene/Cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient
Author Koroloff, Natasha; Boots, Robert; Lipman, Jeff; Thomas, Peter; Rickard, Claire; Coyer, Fiona
Journal Name Intensive Care Medicine
Year Published 2004
Place of publication Germany
Publisher Springer
Abstract Objective To compare the efficacy of two forms of eye care (hypromellose and Lacri-Lube combination vs polyethylene/Cling wrap covers) for intensive care patients. Design Randomised-controlled trial. Setting University affiliated, tertiary referral hospital. Patients and participants One hundred ten patients with a reduced or absent blink reflex were followed through until they regained consciousness, were discharged from the facility during study enrolment, died or developed a positive corneal ulcer or eye infection. Interventions All patients received standard eye cleansing every 2 h. In addition to this, group one (n=60) received a treatment combining hypromellose drops and Lacri-Lube (HL) to each eye every 2 h. Group two (n=50) had polyethylene covers only placed over the eye to create a moisture chamber. Measurements and results Corneal ulceration was determined using corneal fluorescein stains and mobile slit lamp evaluation, performed daily. No patients had corneal ulceration in the polyethylene cover group, but 4 patients had corneal ulceration in the HL group. Conclusions Polyethylene covers are as effective as HL in reducing the incidence of corneal damage in intensive care patients.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1007/s00134-004-2203-y
Volume 30
Issue Number 6
Page from 1122
Page to 1126
ISSN 0342-4642
Date Accessioned 2007-05-10
Date Available 2009-11-24T05:21:31Z
Language en_AU
Research Centre Griffith Health Institute; Centre for Health Practice Innovation
Faculty Griffith Health Faculty
Subject PRE2009-Clinical Nursing: Secondary (Acute Care); PRE2009-Intensive Care
URI http://hdl.handle.net/10072/26821
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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