Aurocyanide, dicyano-aurate (I), a pharmacologically active metabolite of medicinal gold complexes

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Title Aurocyanide, dicyano-aurate (I), a pharmacologically active metabolite of medicinal gold complexes
Author Graham, G. G.; Whitehouse, Michael; Bushell, Gillian Robin
Journal Name Inflammopharmacology
Year Published 2008
Place of publication Switzerland
Publisher Birkhaeuser Verlag AG
Abstract The aurocyanide anion, Au(CN) 2- , is a human metabolite of several anti-rheumatic gold complexes containing monovalent gold (I) bound to a sulphur ligand. This article reviews some of the chemical and pharmacological properties of this intriguing metabolite, and reports its anti-arthritic and anti-inflammatory activity in rats. Au(CN) 2- is generated from the therapeutic gold complexes by small amounts of hydrogen cyanide, HCN, produced from thiocyanate, SCN-, by myeloperoxidase (MPO) an enzyme in neutrophils which normally produces hypochlorite, OCl-. Thus, Au(CN) 2- is formed at sites of inflammation where activated neutrophils are present. This includes atherosclerotic lesions as well as inflamed joints. MPO also oxidises Au(CN) 2- to Au(III) complexes such as Au(CN) 4- . Au(CN) 2- is normally a very stable monovalent gold complex. In a biological context, only low concentrations are ever present at both extracellular and intracellular sites. However, Au(CN) 2- produced locally may facilitate the cellular uptake and hence the therapeutic and toxic effects of gold drugs. Au(CN) 2- may also be involved in a redox cycle where Au(CN) 2- is oxidised to Au(CN) 4- which is, in turn, reduced back to Au(CN) 2- by endogenous thiols. There are still many questions to be resolved concerning Au(CN) 2- including its intrinsic toxicity and the extent to which it may contribute to the overall anti-arthritic activities of the gold-thiolates from which it is formed in vivo.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1007/s10787-007-0020-y
Volume 16
Issue Number 3
Page from 126
Page to 132
ISSN 0925-4692
Date Accessioned 2009-11-16
Date Available 2010-08-30T07:02:11Z
Language en_AU
Research Centre Griffith Medical Research College
Faculty Faculty of Science, Environment, Engineering and Technology
Subject PRE2009-Cross discipline
URI http://hdl.handle.net/10072/26830
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1a

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