Physiological role of carnosine in contracting muscle

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Title Physiological role of carnosine in contracting muscle
Author Begum, Gulshanara; Cunliffe, Adam; Leveritt, Michael
Journal Name International Journal of Sport Nutrition and Exercise Metabolism
Year Published 2005
Place of publication USA
Publisher Human Kinetics Publishers, Inc.
Abstract High-intensity exercise leads to reductions in muscle substrates (ATP, PCr6, and glycogen) and a subsequent accumulation of metabolites (ADP, P, H(+), and Mg(+)) with a possible increase in free radical production. These factors independently and collectively have deleterious effects on muscle, with significant repercussions on high-intensity performance or training sessions. The effect of carnosine on overcoming muscle fatigue appears to be related to its ability to buffer the increased H(+) concentration following high-intensity work. Carnosine, however, has other roles such as an antioxidant, a metal chelator, a Ca(2+) and enzyme regulator, an inhibitor of protein glycosylation and protein-protein cross-linking. To date7comma; only 1 study has investigated the effects of carnosine supplementation (not in pure form) on exercise performance in human subjects and found no improvement in repetitive high-intensity work. Much data has come from in vitro work on animal skeletal muscle fibers or other components of muscle contractile mechanisms. Thus further research needs to be carried out on humans to provide additional understanding on the effects of carnosine in vivo.
Peer Reviewed Yes
Published Yes
Publisher URI
Volume 15
Issue Number 5
Page from 493
Page to 514
ISSN 1526-484X
Date Accessioned 2007-07-03
Language en_AU
Research Centre Menzies Health Institute Qld
Faculty Griffith Health Faculty
Subject PRE2009-Exercise Physiology
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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