Health benefits of a natural carotenoid rich oil: a proposed mechanism of protection against ischaemi/reperfusion injury

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Title Health benefits of a natural carotenoid rich oil: a proposed mechanism of protection against ischaemi/reperfusion injury
Author Rooyen, Jacques van; Esterhuyse, Adriaan J; Engelbrecht, Anna- Mart; Du Toit, Eugene
Journal Name Asia Pacific Journal of Clinical Nutrition
Year Published 2008
Place of publication Australia
Publisher HEC Press
Abstract Numerous studies have reported the protective properties of carotenoid supplementation against skin and eye associated diseases. However, conflicting data concerning the efficacy of β-carotene in the pathogenesis of cancers and cardiovascular disease exist. It has been shown that β-carotene is an effective antioxidant on its own or in combination with other antioxidants. Red palm oil (RPO) is a potent anti-oxidant rich oil which consists of carotenoids, tocopherols, tocotrienols and lycopenes as well as lipid fractions such as squalene, saturated and unsaturated fatty acids (which maximize absorption of these anti-oxidants) and Co-enzyme Q10. α and β-carotene account for more than 90% of the total carotene in RPO. It is known that ischaemia/reperfusion-induced injury causes an imbalance in oxygen supply which can lead to oxidative stress in the heart. It has been shown that the mitogen-activated protein kinases (MAPKs), PKB/Akt and the NO-cGMP all play vital roles in ischaemia/ reperfusion injury in the heart. Therefore, our review mainly focuses on the signaling pathways involved in functional recovery induced by a natural carotenoid oil after ischaemia/reperfusion injury
Peer Reviewed Yes
Published Yes
Publisher URI http://apjcn.nhri.org.tw/server/APJCN/Volume17/vol17suppl.1/316-319S19-3.pdf
Copyright Statement Copyright 2008 HEC Press. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Volume 17
Page from 316
Page to 319
ISSN 0964-7058
Date Accessioned 2009-06-29
Date Available 2011-11-07T06:54:08Z
Language en_AU
Research Centre Griffith Health Institute
Faculty Griffith Health Faculty
Subject Cardiology (incl Cardiovascular Diseases)
URI http://hdl.handle.net/10072/26917
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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