Risk factors for schizophrenia. Follow-up data from the Northern Finland 1966 Birth Cohort Study

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Title Risk factors for schizophrenia. Follow-up data from the Northern Finland 1966 Birth Cohort Study
Author Isohanni, Matti; Miettunen, Jouko; Mäki, Pirjo; Murray, Graham K.; Ridler, Khanum; Lauronen, Erkia; Moilanen, Kristiina; Alaräisänen, Antti; Haapea, Marianne; Isohanni, Irene; Ivleva, Elena; Tamminga, Carol; McGrath, John; Koponen, Hannu
Journal Name World Psychiatry
Year Published 2006
Place of publication Italy
Publisher Elsevier Masson
Abstract This paper updates single risk factors identified by the Northern Finland 1966 Birth Cohort Study up to the end of year 2001 or age 34. Impaired performance (e.g., delayed motor or intellectual development) or adverse exposures (e.g., pregnancy and birth complications, central nervous system diseases) are associated with an increased risk for schizophrenia. However, upper social class girls and clever schoolboys also have an increased risk to develop schizophrenia, contrasted to their peers. Individuals who subsequently develop schizophrenia follow a developmental trajectory that partly and subtly differs from that of the general population; this trajectory lacks flexibility and responsiveness compared to control subjects, at least in the early stages. We propose a descriptive, lifespan, multilevel systems model on the development and course of schizophrenia.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.psychiatry.sk/
Volume 5
Issue Number 3
Page from 168
Page to 171
ISSN 1723-8617
Date Accessioned 2009-08-05
Language en_AU
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Epidemiology
URI http://hdl.handle.net/10072/27099
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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