The anti-mutagenic properties of bile pigments

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Title The anti-mutagenic properties of bile pigments
Author Bulmer, Andrew Cameron; Ried, K.; Blanchfield, J.T.; Wagner, K.-H.
Journal Name Mutation Research - Reviews
Year Published 2008
Place of publication Netherlands
Publisher Elsevier BV
Abstract Bile pigments, including bilirubin and biliverdin, are endogenous compounds belonging to the porphyrin family of molecules. In the past, bile pigments and bilirubin in particular were thought of as useless by-products of heme catabolism that can be toxic if they accumulate. However, in the past 20 years, research probing the physiological relevance of bile pigments has been mounting, with evidence to suggest bile pigments possess significant antioxidant and anti-mutagenic properties. More specifically, bile pigments are potent peroxyl radical scavengers and inhibit the mutagenic effects of a number of classes of mutagens (polycyclic aromatic hydrocarbons, heterocyclic amines, oxidants). Coincidentally, persons with elevated circulating bilirubin concentrations have a reduced prevalence of cancer and cardio-vascular disease. Despite the encouraging in vitro anti-mutagenic effects of bile pigments, relatively little research has been conducted on their inhibitory capacity in bacterial and cultured cell assays of mutation, which might link the existing in vitro and in vivo observations. This is the first review to summarise the published data and it is our hope it will stimulate further research on these potentially preventative compounds.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.elsevier.com/wps/find/journaldescription.cws_home/506097/description#description
Alternative URI http://dx.doi.org/10.1016/j.mrrev.2007.05.001
Volume 658
Issue Number 1-2
Page from 28
Page to 41
ISSN 1383-5742
Date Accessioned 2009-11-05
Date Available 2009-12-14T03:13:26Z
Language en_AU
Research Centre Heart Foundation Research Centre; Griffith Health Institute
Faculty Griffith Health Faculty
Subject Medical and Health Sciences
URI http://hdl.handle.net/10072/27411
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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