Anti-ganglioside antibody induction by swine (A/NJ/1976/H1N1) and other influenza vaccines: Insights into vaccine-associated Guillain-Barre syndrome

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Title Anti-ganglioside antibody induction by swine (A/NJ/1976/H1N1) and other influenza vaccines: Insights into vaccine-associated Guillain-Barre syndrome
Author Nachamkin, Irving; Shadomy, Sean V.; Moran, Anthony Patrick; Cox, Nancy; Fitzgerald, Collette; Ung, Huong; Corcoran, Adrian T.; Iskander, John K.; Schonberger, Lawrence B.; Chen, Robert T.
Journal Name Journal of Infectious Diseases
Year Published 2008
Place of publication USA
Publisher University of Chicago Press
Abstract Background: Receipt of an A/NJ/1976/H1N1 “swine flu” vaccine in 1976, unlike receipt of influenza vaccines used in subsequent years, was strongly associated with the development of the neurologic disorder Guillain‐Barré syndrome (GBS). Anti‐ganglioside antibodies (e.g., anti‐GM1) are associated with the development of GBS, and we hypothesized that the swine flu vaccine contained contaminating moieties (such as Campylobacter jejuni antigens that mimic human gangliosides or other vaccine components) that elicited an anti‐GM1 antibody response in susceptible recipients. Methods: Surviving samples of monovalent and bivalent 1976 vaccine, comprising those from 3 manufacturers and 11 lot numbers, along with several contemporary vaccines were tested for hemagglutinin (HA) activity, the presence of Campylobacter DNA, and the ability to induce anti‐Campylobacter and anti‐GM1 antibodies after inoculation into C3H/HeN mice. Results: We found that, although C. jejuni was not detected in 1976 swine flu vaccines, these vaccines induced anti‐GM1 antibodies in mice, as did vaccines from 1991–1992 and 2004–2005. Preliminary studies suggest that the influenza HA induces anti‐GM1 antibodies. Conclusions: Influenza vaccines contain structures that can induce anti‐GM1 antibodies after inoculation into mice. Further research into influenza vaccine components that elicit anti‐ganglioside responses and the role played by these antibodies (if any) in vaccine‐associated GBS is warranted.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.journals.uchicago.edu/toc/jid/current
Alternative URI http://dx.doi.org/10.1086/589624
Volume 198
Issue Number 2
Page from 226
Page to 233
ISSN 0022-1899
Date Accessioned 2009-03-03
Date Available 2009-12-14T07:53:39Z
Language en_AU
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Bacteriology; Cellular Immunology
URI http://hdl.handle.net/10072/27448
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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