Dietary red palm oil improves reperfusion cardiac function in the isolated perfused rat heart of animals fed a high cholesterol diet

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Title Dietary red palm oil improves reperfusion cardiac function in the isolated perfused rat heart of animals fed a high cholesterol diet
Author Esterhuyse, A.J.; Du Toit, Eugene; Benadè, A.J.S.; Rooyen, J. van
Journal Name Prostaglandins, Leukotrienes & Essential Fatty Acids
Year Published 2005
Place of publication Edinburgh, Scotland.
Publisher Churchill Livingstone
Abstract It has been shown that dietary red palm oil (RPO) supplementation improved reperfusion function. However, no exact protective cellular mechanisms have been established. Our aim was to search for a possible cellular mechanism and a role for fatty acids. Rats were fed a standard rat chow, plus cholesterol and/or RPO-supplementation for 6 weeks. Functional recovery, myocardial phospholipid and cAMP/cGMP levels were determined in isolated rat hearts subjected to 25 min of normothermic total global ischaemia. Dietary RPO in the presence of cholesterol improved aortic output (AO) recovery (63.2±3.06%, P<0.05) vs. cholesterol only (36.5±6.2%). The improved functional recovery in hearts supplemented with RPO vs. control was preceded by an elevation in the cGMP levels early in ischaemia (RPO 132.9±36.3% vs. control 42.7±24.4%, P<0.05). Concurrently, cAMP levels decreased (RPO −8.3±6.9% vs. control 19.9±7.7%, P<0.05). Our data suggest that dietary RPO-supplementation improved reperfusion AO through mechanisms that may include activation of the NO-cGMP and inhibition of the cAMP pathway.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.elsevier.com/wps/find/journaldescription.cws_home/623065/description#description
Alternative URI http://dx.doi.org/10.1016/j.plefa.2004.10.014
Volume 72
Issue Number 3
Page from 153
Page to 161
ISSN 0952-3278
Date Accessioned 2009-06-29
Date Available 2009-12-14T07:53:46Z
Language en_AU
Research Centre Griffith Health Institute
Faculty Griffith Health Faculty
Subject Cardiology (incl Cardiovascular Diseases)
URI http://hdl.handle.net/10072/27450
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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