Ageing does not influence the sleep-related decrease in the hypercapnic ventilatory response

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Title Ageing does not influence the sleep-related decrease in the hypercapnic ventilatory response
Author Browne, H.A.K.; Adams, Lewis; Simonds, A.K.; Morrell, M.J.
Journal Name European Respiratory Journal
Year Published 2003
Place of publication Switzerland
Publisher European Respiratory Society
Abstract In young people, a sleep-related reduction in the gain of the ventilatory chemoreflex feedback loop occurs; in the elderly, it has been reported that no sleeprelated reduction occurs. A relatively high loop gain could contribute to periodic breathing and central sleep apnoea in the elderly. This study tested the hypothesis that ageing is associated with a reduction in the magnitude of the sleep-related decrease in the hypercapnic ventilatory response (HCVR). The HCVR was measured using a steady state method, awake and asleep, in groups (n=10) of elderly (66–81 yrs) and young (23–35 yrs) nonapnoeics. Upper airway resistance was maintained close to wakefulness levels using continuous positive airway pressure (mean sleep-related increase in resistance: elderly 1.6¡1.2 cmH2O?L?s-1, young 1.2¡0.8 cmH2O?L?s-1). The sleep-related decrease in the HCVR was similar in the elderly and young groups (elderly: wake 0.14¡0.06 and sleep 0.06¡0.02 L?min-1?kPa and young, wake 0.19¡0.07 and sleep 0.10¡0.04 L?min-1?kPa). Ageing per se was shown not to change the magnitude of the sleep-related decrease in hypercapnic ventilatory response. The authors speculate that age-related changes in the hypercapnic ventilatory response are unlikely to contribute to the increased prevalence of central sleep apnoea in the elderly.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.erj.ersjournals.com/
Alternative URI http://dx.doi.org/10.1183/09031936.03.00039002
Volume 21
Issue Number 3
Page from 523
Page to 529
ISSN 0903-1936
Date Accessioned 2006-08-04
Language en_AU
Research Centre Griffith Health Institute
Faculty Griffith Health Faculty
Subject PRE2009-Geriatrics and Gerontology; PRE2009-Respiratory Diseases; PRE2009-Systems Physiology
URI http://hdl.handle.net/10072/27458
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1a

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