Proposed mechanisms for red palm oil induced cardioprotection in a model of hyperlipidaemia in the rat

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Title Proposed mechanisms for red palm oil induced cardioprotection in a model of hyperlipidaemia in the rat
Author Esterhuyse, Johan S.; Rooyen, Jacques van; Strijdom, Hans; Bester, Dirk; Du Toit, Eugene
Journal Name Prostaglandins, Leukotrienes & Essential Fatty Acids
Year Published 2006
Place of publication Edinburgh, Scotland
Publisher Churchill Livingstone
Abstract High-cholesterol diets alter myocardial and vascular NO-cGMP signaling and have been implicated in ischaemic/reperfusion injury. We investigated the effects of dietary red palm oil (RPO) containing fatty acids, carotonoids, tocopherols and tocotrienols on myocardial ischaemic tolerance and NO-cGMP pathway function in the rat. Wistar rats were fed a standard rat chow±RPO, or a standard rat chow+cholesterol±RPO diet. Myocardial mechanical function and NO-cGMP signaling pathway intermediates were determined before, during and after 25 min ischaemia. RPO-supplementation improved aortic output recovery and increased myocardial ischaemic cGMP concentrations. Simulated ischaemia (hypoxia) increased cardiomyocyte nitric oxide levels in the two RPO supplemented groups, but not in control non-supplemented groups. RPO supplementation also increased hypoxic nitric oxide levels in the control diet fed, but not the cholesterol fed rats. These data suggest that dietary RPO may improve myocardial ischaemic tolerance by increasing bioavailability of NO and improving NO-cGMP signaling in the heart.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.sciencedirect.com/science/journal/09523278
Alternative URI http://dx.doi.org/10.1016/j.plefa.2006.07.001
Volume 75
Issue Number 6
Page from 375
Page to 384
ISSN 0952-3278
Date Accessioned 2009-06-29
Date Available 2009-12-14T07:55:24Z
Language en_AU
Research Centre Griffith Health Institute; Heart Foundation Research Centre
Faculty Griffith Health Faculty
Subject Cardiology (incl Cardiovascular Diseases)
URI http://hdl.handle.net/10072/27479
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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