dc.contributor.author | Ulett, Kimberly B | |
dc.contributor.author | Benjamin, William H | |
dc.contributor.author | Zhuo, Fenglin | |
dc.contributor.author | Xiao, Meng | |
dc.contributor.author | Kong, Fanrong | |
dc.contributor.author | Gilbert, Gwendolyn L | |
dc.contributor.author | Schembri, Mark A | |
dc.contributor.author | Ulett, Glen C | |
dc.date.accessioned | 2017-05-03T15:29:32Z | |
dc.date.available | 2017-05-03T15:29:32Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 0095-1137 | |
dc.identifier.doi | 10.1128/JCM.00154-09 | |
dc.identifier.uri | http://hdl.handle.net/10072/27675 | |
dc.description.abstract | Serotypes of group B streptococcus (GBS) that cause urinary tract infection (UTI) are poorly characterized. We conducted a prospective study of GBS UTI in adults to define the clinical and microbiological characteristics of these infections, including which serotypes cause disease. Patients who had GBS cultured from urine over a 1-year period were grouped according to symptoms, bacteriuria, and urinalysis. Demographic data were obtained by reviewing medical records. Isolates were serotyped by latex agglutination and multiplex PCR-reverse line blotting (mPCR/RLB). Antibiotic susceptibilities were determined by disc diffusion. GBS was cultured from 387/34,367 consecutive urine samples (1.1%): 62 patients had bacteriuria of >107 CFU/liter and at least one UTI symptom; of these patients, 31 had urinary leukocyte esterase and pyuria (others not tested), 50 (81%) had symptoms consistent with cystitis, and 12 (19%) had symptoms of pyelonephritis. Compared with controls (who had GBS isolated without symptoms), a prior history of UTI was an independent risk factor for disease. Increased age was also significantly associated with acute infection. Serotyping results were consistent between latex agglutination and mPCR/RLB for 331/387 (85.5%) isolates; 22 (5.7%) and 7 (1.8%) isolates were nontypeable with antisera and by mPCR/RLB, respectively; and 45/56 (80.4%) isolates with discrepant results were typed by mPCR/RLB as belonging to serotype V. Serotypes V, Ia, and III caused the most UTIs; serotypes II, Ib, and IV were less common. Nontypeable GBS was not associated with UTI. Erythromycin (39.5%) and clindamycin (26.4%) resistance was common. We conclude that a more diverse spectrum of GBS serotypes causes UTI than previously recognized, with the exception of nontypeable GBS. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.format.extent | 226205 bytes | |
dc.format.mimetype | application/pdf | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | American Scoiety for Microbiology | |
dc.publisher.place | USA | |
dc.publisher.uri | http://jcm.asm.org/ | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 2055 | |
dc.relation.ispartofpageto | 2060 | |
dc.relation.ispartofissue | 7 | |
dc.relation.ispartofjournal | Journal of Clinical Microbiology | |
dc.relation.ispartofvolume | 47 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Biological sciences | |
dc.subject.fieldofresearch | Agricultural, veterinary and food sciences | |
dc.subject.fieldofresearch | Biomedical and clinical sciences | |
dc.subject.fieldofresearch | Medical bacteriology | |
dc.subject.fieldofresearchcode | 31 | |
dc.subject.fieldofresearchcode | 30 | |
dc.subject.fieldofresearchcode | 32 | |
dc.subject.fieldofresearchcode | 320701 | |
dc.title | Diversity of Group B Streptococcus Serotypes Causing Urinary Tract Infection in Adults | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.rights.copyright | © 2009 American Society of Microbiology. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version. | |
gro.date.issued | 2015-05-31T22:17:07Z | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Ulett, Glen C. | |