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dc.contributor.authorUlett, Kimberly B
dc.contributor.authorBenjamin, William H
dc.contributor.authorZhuo, Fenglin
dc.contributor.authorXiao, Meng
dc.contributor.authorKong, Fanrong
dc.contributor.authorGilbert, Gwendolyn L
dc.contributor.authorSchembri, Mark A
dc.contributor.authorUlett, Glen C
dc.date.accessioned2017-05-03T15:29:32Z
dc.date.available2017-05-03T15:29:32Z
dc.date.issued2009
dc.identifier.issn0095-1137
dc.identifier.doi10.1128/JCM.00154-09
dc.identifier.urihttp://hdl.handle.net/10072/27675
dc.description.abstractSerotypes of group B streptococcus (GBS) that cause urinary tract infection (UTI) are poorly characterized. We conducted a prospective study of GBS UTI in adults to define the clinical and microbiological characteristics of these infections, including which serotypes cause disease. Patients who had GBS cultured from urine over a 1-year period were grouped according to symptoms, bacteriuria, and urinalysis. Demographic data were obtained by reviewing medical records. Isolates were serotyped by latex agglutination and multiplex PCR-reverse line blotting (mPCR/RLB). Antibiotic susceptibilities were determined by disc diffusion. GBS was cultured from 387/34,367 consecutive urine samples (1.1%): 62 patients had bacteriuria of >107 CFU/liter and at least one UTI symptom; of these patients, 31 had urinary leukocyte esterase and pyuria (others not tested), 50 (81%) had symptoms consistent with cystitis, and 12 (19%) had symptoms of pyelonephritis. Compared with controls (who had GBS isolated without symptoms), a prior history of UTI was an independent risk factor for disease. Increased age was also significantly associated with acute infection. Serotyping results were consistent between latex agglutination and mPCR/RLB for 331/387 (85.5%) isolates; 22 (5.7%) and 7 (1.8%) isolates were nontypeable with antisera and by mPCR/RLB, respectively; and 45/56 (80.4%) isolates with discrepant results were typed by mPCR/RLB as belonging to serotype V. Serotypes V, Ia, and III caused the most UTIs; serotypes II, Ib, and IV were less common. Nontypeable GBS was not associated with UTI. Erythromycin (39.5%) and clindamycin (26.4%) resistance was common. We conclude that a more diverse spectrum of GBS serotypes causes UTI than previously recognized, with the exception of nontypeable GBS.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent226205 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Scoiety for Microbiology
dc.publisher.placeUSA
dc.publisher.urihttp://jcm.asm.org/
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom2055
dc.relation.ispartofpageto2060
dc.relation.ispartofissue7
dc.relation.ispartofjournalJournal of Clinical Microbiology
dc.relation.ispartofvolume47
dc.rights.retentionY
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchAgricultural, veterinary and food sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchMedical bacteriology
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode30
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode320701
dc.titleDiversity of Group B Streptococcus Serotypes Causing Urinary Tract Infection in Adults
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2009 American Society of Microbiology. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2015-05-31T22:17:07Z
gro.hasfulltextFull Text
gro.griffith.authorUlett, Glen C.


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