CO2 retention in lung disease; could there be a pre-existing difference in respiratory physiology

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Title CO2 retention in lung disease; could there be a pre-existing difference in respiratory physiology
Author Dunroy, Helen M.A.; Adams, Lewis; Corfield, Douglas R.; Morrell, Mary J.
Journal Name Respiration Physiology & Neurobiology
Year Published 2003
Place of publication Netherlands
Publisher Elsevier BV
Abstract Some patients with lung disease retain CO2, while others with similar lung function do not. This could be explained if CO2 retainers had a pre-existing low hypercapnic ventilatory response (HCVR) and, from this, a tendency to retain CO2. To test if such a phenomenon exists in healthy people, we determined the change in end-tidal PCO2 (ΔPETCO2) produced by the addition of a dead-space (DS), during wakefulness and sleep, and related this to the HCVR measured awake. The group mean (n=14) HCVR slope was 2.2±1.1 (S.D.) L min−1 mmHg−1. The ΔPETCO2 with the application of DS was 1.6±1.6 mmHg awake and 2.6±2.2 mmHg asleep. During wakefulness the ?PETCO2 with DS did not correlate with the HCVR slope. However, during sleep, four subjects had a marked increase in the ΔPETCO2 (3.7, 4.3, 6.2, 8.0 mmHg) and a relatively low HCVR (slope 1.5, 1.7, 1.5, 1.7 L min−1 mmHg−1, respectively). We speculate that such individuals, should they develop lung disease, may be predisposed to retain CO2.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.elsevier.com/locate/resphysiol
Alternative URI http://dx.doi.org/10.1016/S1569-9048(03)00080-6
Volume 136
Issue Number 2-3
Page from 179
Page to 186
ISSN 1569-9048
Date Accessioned 2006-08-04
Date Available 2009-12-17T22:31:05Z
Language en_AU
Research Centre Griffith Health Institute; Heart Foundation Research Centre
Faculty Griffith Health Faculty
Subject PRE2009-Systems Physiology
URI http://hdl.handle.net/10072/27695
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1a

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