Non-conventional toxins from Elapid venoms.

There are no files associated with this record.

Title Non-conventional toxins from Elapid venoms.
Author Nirthanan, S. Niru; Gopalakrishnakone, P.; Gwee, M. C. E.; Khoo, H. E.; Kini, R. M.
Journal Name Toxicon
Year Published 2003
Place of publication Amsterdam
Publisher Elsevier Science
Abstract Non-conventional toxins constitute a poorly characterized class of three-finger toxins isolated exclusively from Elapidae venoms. These toxins are monomers of 62–68 amino acid residues and contain five disulfide bridges. However, unlike α/κ-neurotoxins and κ-neurotoxins which have the fifth disulfide bridge in their middle loop (loop II), the fifth disulfide bridge in non-conventional toxins is located in loop I (N-terminus loop). Overall, non-conventional toxins share ~28–42% identity with other three-finger toxins including α-neurotoxins, α/κ-neurotoxins and κ-neurotoxins. Recent structural studies have revealed that non-conventional toxins also display the typical three-finger motif. Non-conventional toxins are typically characterized by a lower order of toxicity (LD50~5–80 mg/kg) in contrast to prototype α-neurotoxins (LD50~0.04–0.3 mg/kg) and hence they are also referred to as 'weak toxins'. Further, it is generally assumed that non-conventional toxins target muscle (α2βγδ) receptors with low affinities several orders of magnitude lower than α-neurotoxins and α/κ-neurotoxins. However, it is now known that some non-conventional toxins also antagonize neuronal α7 nicotinic acetylcholine receptors. Hence, non-conventional toxins are not a functionally homogeneous group and other, yet unknown, molecular targets for this class of snake venom toxins may exist. Non-conventional toxins may therefore be a useful source of ligands with novel biological activity targeting the plethora of neuronal nicotinic receptors as well as other physiological processes.
Peer Reviewed Yes
Published Yes
Publisher URI
Alternative URI
Volume 41
Issue Number 4
Page from 397
Page to 407
ISSN 0041-0101
Date Accessioned 2009-07-09
Language en_AU
Research Centre Menzies Health Institute Qld
Faculty Griffith Health Faculty
Subject Biochemistry and Cell Biology; Physiology
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

Show simple item record

Griffith University copyright notice