Morphine-tolerant mice exhibit a profound and persistent cardioprotective phenotype.

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Title Morphine-tolerant mice exhibit a profound and persistent cardioprotective phenotype.
Author Peart, Jason Nigel John; Gross, Garrett J.
Journal Name Circulation.
Year Published 2004
Place of publication USA
Publisher Lippincott, Williams and Wilkins
Abstract Background— Morphine and other opioids continue to be used as the major treatment for acute pain both before and after surgery. In this regard, much research has focused on the mechanisms of morphine tolerance and dependence in the central nervous system; however, few studies have examined the effect of morphine on peripheral organs, such as the heart, in morphine-tolerant animals. Here, we examine the effect of tolerance to the analgesic effect of morphine on ischemic tolerance in mice after prolonged morphine exposure and withdrawal. Methods and Results— Male C57/BL6 mice were implanted subcutaneously with either placebo or morphine pellets (25 or 75 mg). After prolonged exposure to and/or withdrawal from morphine or placebo, the hearts were excised and subjected to 25 minutes of ischemia and 45 minutes of reperfusion. Morphine-tolerant mice exhibited a markedly improved functional recovery compared with placebo and mice subjected to acute morphine. Lactate dehydrogenase release was also significantly reduced. The protection observed was equieffective 48 hours after withdrawal of pellet, whereas the onset of protection preceded analgesic tolerance. Conclusions— These data demonstrate that chronic exposure to morphine unexpectedly results in a profound and persistent cardioprotective phenotype.
Peer Reviewed Yes
Published Yes
Publisher URI http://circ.ahajournals.org/
Alternative URI http://dx.doi.org/10.1161/01.CIR.0000121422.85989.BD
Copyright Statement Copyright 2004 Lippincott, Williams & Wilkins. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
Volume 109
Page from 1219
Page to 1222
ISSN 0009-7322
Date Accessioned 2006-07-26
Date Available 2009-12-21T03:16:23Z
Language en_AU
Research Centre Griffith Health Institute; Heart Foundation Research Centre
Faculty Griffith Health Faculty
Subject PRE2009-Clinical Pharmacology and Therapeutics
URI http://hdl.handle.net/10072/27833
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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