Total Synthesis of Spongistatin 1 (Altohyrtin A): A Tale of Ten Aldols

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Title Total Synthesis of Spongistatin 1 (Altohyrtin A): A Tale of Ten Aldols
Author Paterson, Ian; Coster, Mark J.
Book Title Strategies and Tactics in Organic Synthesis
Editor Michael Harmata
Year Published 2004
Place of publication Oxford
Publisher Elsevier
Abstract A review on the total synthesis of spongistatin 1/altohyrtin A, an extremely rare marine macrolide with a seductively complex structure in combination with displaying promising anticancer properties. Topics covered include the retrosynthetic anal.; the AB- and CD-spiroacetal subunit; the Northern and Southern hemisphere; Wittig coupling of the Northern and Southern hemispheres; and final steps of structure-activity relationships.
Peer Reviewed Yes
Published Yes
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Copyright Statement Self-archiving is not yet supported by this publisher. Please refer to the publisher's website or contact the author(s) for more information.
Volume 4
Chapter Number 8
Page from 211
Page to 245
ISBN 0-12-450287-3
Date Accessioned 2007-06-08
Language en_US
Research Centre Eskitis Institute for Drug Discovery
Faculty Eskitis, Inst Cell&Molecular Therapies
Subject PRE2009-Organic Chemical Synthesis
Publication Type Book Chapters
Publication Type Code b1x

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