The Macrophage Inducible c-type lectin, Mincle, is an essential component of the innate-immune response to Candida albicans

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Title The Macrophage Inducible c-type lectin, Mincle, is an essential component of the innate-immune response to Candida albicans
Author Wells, Christine A; Salvage-Jones, Judith; Beckhouse, Anthony; Hitchens, Kelly; Ashman, Robert; Ma, Bo; Stewart, Lauren; Lebus, Daniel; Sobieszczuk, Peter
Publication Title Program and Abstracts for the 2007 Meeting of the Society for Glycobiology
Year Published 2007
Place of publication Nashville, TN, USA
Publisher Society for Glycobiology
Abstract The recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in anti-fungal immunity, but few carbohydrate receptors have been characterised, despite the number and diversity of lectins expressed by innate immune cells. We demonstrate a novel role for the c-type lectin Mincle in macrophage responses to C. albicans. Mincle was observed to localise in the phagocytic cup of macrophages in response to a range of stimuli. Loss of Mincle reduced macrophage TNF production both in vivo and in vitro, but did not alter the number of Candida yeast phagocytised. Mice lacking Mincle showed a significantly increased susceptibility to systemic candidiasis. Thus Mincle contributes a novel and non-redundant role in the induction of inflammatory signalling in response to C. albicans infection.
Peer Reviewed No
Published Yes
Publisher URI http://www.glycobiology.org/
Conference name Annual Conference of the Society for Glycobiology
Location Boston, MA, USA
Date From 2007-11-11
Date To 2007-11-14
URI http://hdl.handle.net/10072/28193
Date Accessioned 2009-07-22
Date Available 2010-01-11T07:55:09Z
Language en_AU
Faculty Faculty of Science, Environment, Engineering and Technology
Subject PRE2009-Biochemistry and Cell Biology
Publication Type Conference Publications (Extract Paper)
Publication Type Code e3

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