Expression of developmentally regulated transcription factors in Merkel cell carcinoma

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Title Expression of developmentally regulated transcription factors in Merkel cell carcinoma
Author Leonard, J. H.; Cook, A. L.; Gele, M. Van; Speleman, F.; Sturm, R. A.
Book Title The Merkel Cell Structure-Development-Function-Cancerogenesis
Year Published 2003
Place of publication London
Publisher Springer
Abstract We have examined a number of developmentally regulated transcription factors for expression in Merkel cells and MCC cell lines and demonstrated that their expression patterns may be prognostic in MCC. We have shown that human Merkel cells from adult scalp hair follicle and from neonatal foreskin epidermal sheets express Brn-3c and HATH1. In addition, results demonstrate that the novel Merkel binding activity complex MNF contains Brn-3c. Moreover, Classic lines which retain neuroendocrine phenotype, are slow growing in culture, grow in suspension and are thought to be less aggressive, retain Brn-2, Brn-3c and HATH1 expression, whereas Variant suspension lines which no longer express NE markers retain Brn-2 and Brn-3c expression, but lack HATH1. Further, Type IV Variant lines which grow as adherent monolayers have shorter doubling times, are more radiation- resistant and have higher cloning efficiencies in soft agar, all thought to be indicative of aggressive tumours, have reduced or no Brn-2 proteins and lack expression of Brn-3c and HATH1 transcription factors.
Peer Reviewed Yes
Published Yes
Publisher URI
Chapter Number 30
Page from 203
Page to 218
ISBN 3540003746
Date Accessioned 2009-07-24
Language en_AU
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Cell Development, Proliferation and Death
Publication Type Book Chapters
Publication Type Code b1x

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