Temperature change as a probe of muscle crossbridge kinetics: a review and discussion

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Title Temperature change as a probe of muscle crossbridge kinetics: a review and discussion
Author Woledge, R. C.; Barclay, Christopher John; Curtin, N. A.
Journal Name Proceedings of the Royal Society of London, Series B: Biological Sciences
Year Published 2009
Place of publication London
Publisher Royal Society Publishing
Abstract Following the ideas introduced by Huxley (Huxley 1957, Prog. Biophys. Biophys. Chem. 7, 255-318), it is generally supposed that muscle contraction is produced by temporary links, called crossbridges, between myosin and actin filaments, which form and break in a cyclic process driven by ATP splitting. Here we consider the interaction of the energy in the crossbridge, in its various states, and the force exerted. We discuss experiments in which the mechanical state of the crossbridge is changed by imposed movement and the energetic consequence observed as heat output and the converse experiments in which the energy content is changed by altering temperature and the mechanical consequences are observed. The thermodynamic relationship between the experiments is explained and, at the first sight, the relationship between the results of these two types of experiment appears paradoxical. However, we describe here how both of them can be explained by a model in which mechanical and energetic changes in the crossbridges occur in separate steps in a branching cycle.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1098/rspb.2009.0177
Volume 276
Page from 2685
Page to 2695
ISSN 0962-8452
Date Accessioned 2009-09-28
Language en_AU
Research Centre Menzies Health Institute Qld
Faculty Griffith Health Faculty
Subject Animal Physiology - Biophysics
URI http://hdl.handle.net/10072/29282
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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