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dc.contributor.authorWoledge, R.
dc.contributor.authorBarclay, Chris
dc.contributor.authorCurtin, N.
dc.date.accessioned2017-05-03T11:39:56Z
dc.date.available2017-05-03T11:39:56Z
dc.date.issued2009
dc.date.modified2010-08-24T06:50:02Z
dc.identifier.issn09628452
dc.identifier.doi10.1098/rspb.2009.0177
dc.identifier.urihttp://hdl.handle.net/10072/29282
dc.description.abstractFollowing the ideas introduced by Huxley (Huxley 1957, Prog. Biophys. Biophys. Chem. 7, 255-318), it is generally supposed that muscle contraction is produced by temporary links, called crossbridges, between myosin and actin filaments, which form and break in a cyclic process driven by ATP splitting. Here we consider the interaction of the energy in the crossbridge, in its various states, and the force exerted. We discuss experiments in which the mechanical state of the crossbridge is changed by imposed movement and the energetic consequence observed as heat output and the converse experiments in which the energy content is changed by altering temperature and the mechanical consequences are observed. The thermodynamic relationship between the experiments is explained and, at the first sight, the relationship between the results of these two types of experiment appears paradoxical. However, we describe here how both of them can be explained by a model in which mechanical and energetic changes in the crossbridges occur in separate steps in a branching cycle.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherRoyal Society Publishing
dc.publisher.placeLondon
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom2685
dc.relation.ispartofpageto2695
dc.relation.ispartofjournalProceedings of the Royal Society of London, Series B: Biological Sciences
dc.relation.ispartofvolume276
dc.rights.retentionY
dc.subject.fieldofresearchAnimal Physiology - Biophysics
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchAgricultural and Veterinary Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode060601
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode07
dc.subject.fieldofresearchcode11
dc.titleTemperature change as a probe of muscle crossbridge kinetics: a review and discussion
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2009
gro.hasfulltextNo Full Text
gro.griffith.authorBarclay, Chris


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