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dc.contributor.authorHolmes, Roger S
dc.contributor.authorGlenn, Jeremy P
dc.contributor.authorVandeBerg, John L
dc.contributor.authorCox, Laura A
dc.date.accessioned2017-05-03T16:58:27Z
dc.date.available2017-05-03T16:58:27Z
dc.date.issued2009
dc.date.modified2010-08-16T06:48:58Z
dc.identifier.issn0047-2565
dc.identifier.doi10.1111/j.1600-0684.2008.00315.x
dc.identifier.urihttp://hdl.handle.net/10072/29362
dc.description.abstractBackground Carboxylesterase (CES) is predominantly responsible for the detoxification of a wide range of drugs and narcotics, and catalyze several reactions in cholesterol and fatty acid metabolism. Studies of the genetic and biochemical properties of primate CES may contribute to an improved understanding of human disease, including atherosclerosis, obesity and drug addiction, for which non-human primates serve as useful animal models. Methods We cloned and sequenced baboon CES1 and CES2 and used in vitro and in silico methods to predict protein secondary and tertiary structures, and examined evolutionary relationships for these enzymes with other primate and mouse CES orthologs. Results and Conclusions We found that baboon CES1 and CES2 proteins retained extensive similarity with human CES1 and CES2, shared key structural features reported for human CES1, and showed family specific sequences consistent with their multimeric and monomeric subunit structures respectively.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent190249 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Munksgaard
dc.publisher.placeDenmark
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom27
dc.relation.ispartofpageto38
dc.relation.ispartofjournalJournal of Medical Primatology
dc.relation.ispartofvolume38
dc.rights.retentionY
dc.subject.fieldofresearchGenomics
dc.subject.fieldofresearchZoology
dc.subject.fieldofresearchVeterinary sciences
dc.subject.fieldofresearchcode310509
dc.subject.fieldofresearchcode3109
dc.subject.fieldofresearchcode3009
dc.titleBaboon carboxylesterases 1 and 2: sequences, structures and phylogenetic relationships with human and other primate carboxylesterases
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2009 John Wiley & Sons A/S. This is the author-manuscript version of the paper. Reproduced in accordance with the copyright policy of the publisher.The definitive version is available at www.interscience.wiley.com
gro.date.issued2009
gro.hasfulltextFull Text
gro.griffith.authorHolmes, Roger S.


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