Prevalence of smell loss in Parkinson's disease – A multicenter study

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Title Prevalence of smell loss in Parkinson's disease – A multicenter study
Author Haehner, A.; Boesveldt, S.; Berendse, H. W.; Mackay-Sim, Alan; Fleischmann, Jana; Silburn, Peter Allen; Johnston, Amy Nicole Burne; Mellick, George; Herting, B.; Reichmann, H.; Hummel, T.
Journal Name Parkinsonism and Related Disorders
Editor R. F. Pfeiffer, Z.K. Wszolek
Year Published 2009
Place of publication United Kingdom
Publisher Elsevier Ltd
Abstract Previous data on the prevalence of olfactory dysfunction in Parkinson's disease (PD) range from 45% to 90%. The present multicenter study aimed to provide data on the prevalence of smell loss in a large sample of PD patients from three independent populations. Olfactory sensitivity was tested in 400 patients from Australia, Germany, and The Netherlands by means of a psychophysical olfactory test, the ''Sniffin' Sticks'', which is comprised of 3 subtests of olfactory function. Out of the total number of patients 45.0% presented as functionally anosmic, 51.7% were hyposmic, whereas only 3.3% were normosmic. This indicates that 96.7% of PD patients present with significant olfactory loss when compared to young normosmic subjects. This figure falls to 74.5%, however, when adjusted to age-related norms. Thus, olfactory dysfunction should be considered as a reliable marker of the disease.
Peer Reviewed Yes
Published Yes
Alternative URI
Volume 15
Issue Number 7
Page from 490
Page to 494
ISSN 1353-8020
Date Accessioned 2009-10-09
Language en_AU
Research Centre Centre for Health Practice Innovation; Eskitis Institute for Drug Discovery
Faculty Faculty of Science, Environment, Engineering and Technology
Subject PRE2009-Neurology and Neuromuscular Diseases; PRE2009-Sensory Systems
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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