Current status of pharmacogenomics testing for anti-tumour drug therapies: approaches to non-melanoma skin cancer

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Title Current status of pharmacogenomics testing for anti-tumour drug therapies: approaches to non-melanoma skin cancer
Author Grealy, Rebecca; Griffiths, Lyn
Journal Name Molecular Diagnosis and Therapy
Year Published 2009
Place of publication New Zealand
Publisher Adis International Ltd.
Abstract Skin cancer is one of the most commonly occurring cancer types, with substantial social, physical, and financial burdens on both individuals and societies. Although the role of UV light in initiating skin cancer development has been well characterized, genetic studies continue to show that predisposing factors can influence an individual's susceptibility to skin cancer and response to treatment. In the future, it is hoped that genetic profiles, comprising a number of genetic markers collectively involved in skin cancer susceptibility and response to treatment or prognosis, will aid in more accurately informing practitioners' choices of treatment. Individualized treatment based on these profiles has the potential to increase the efficacy of treatments, saving both time and money for the patient by avoiding the need for extensive or repeated treatment. Increased treatment responses may in turn prevent recurrence of skin cancers, reducing the burden of this disease on society. Currently existing pharmacogenomic tests, such as those that assess variation in the metabolism of the anticancer drug fluorouracil, have the potential to reduce the toxic effects of anti-tumor drugs used in the treatment of non-melanoma skin cancer (NMSC) by determining individualized appropriate dosage. If the savings generated by reducing adverse events negate the costs of developing these tests, pharmacogenomic testing may increasingly inform personalized NMSC treatment.
Peer Reviewed Yes
Published Yes
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Copyright Statement Copyright 2009 Adis Data Information BV. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
Volume 13
Issue Number 2
Page from 65
Page to 72
ISSN 1177-1062
Date Accessioned 2010-04-14
Language en_AU
Research Centre Menzies Health Institute Qld
Faculty Griffith Health Faculty
Subject Genomics
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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