Endurance exercise and DNA stability: is there a link to duration and intensity?

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Title Endurance exercise and DNA stability: is there a link to duration and intensity?
Author Reichhold, Stefanie; Neubauer, Oliver; Bulmer, Andrew Cameron; Knasmuller, Siegfried; Wagner, Karl-Heinz
Journal Name Mutation Research
Year Published 2009
Place of publication Netherlands
Publisher Elsevier
Abstract It is commonly accepted that regular moderate intensity physical activity reduces the risk of developing many diseases. Counter intuitively, however, evidence also exists for oxidative stress resulting from acute and strenuous exercise. Enhanced formation of reactive oxygen and nitrogen species may lead to oxidatively modified lipids, proteins and nucleic acids and possibly disease. Currently, only a few studies have investigated the influence of exercise on DNA stability and damage with conflicting results, small study groups and the use of different sample matrices or methods and result units. This is the first review to address the effect of exercise of various intensities and durations on DNA stability, focusing on human population studies. Furthermore, this article describes the principles and limitations of commonly used methods for the assessment of oxidatively modified DNA and DNA stability. This review is structured according to the type of exercise conducted (field or laboratory based) and the intensity performed (i.e. competitive ultra/endurance exercise or maximal tests until exhaustion). The findings presented here suggest that competitive ultra-endurance exercise (>4 h) does not induce persistent DNA damage. However, when considering the effects of endurance exercise (<4 h), no clear conclusions could be drawn. Laboratory studies have shown equivocal results (increased or no oxidative stress) after endurance or exhaustive exercise. To clarify which components of exercise participation (i.e. duration, intensity and training status of subjects) have an impact on DNA stability and damage, additional carefully designed studies combining the measurement of DNA damage, gene expression and DNA repair mechanisms before, during and after exercise of differing intensities and durations are required.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.sciencedirect.com/science/journal/13835742
Alternative URI http://dx.doi.org/10.1016/j.mrrev.2009.02.002
Volume 682
Issue Number 1
Page from 28
Page to 38
ISSN 0027-5107
Date Accessioned 2010-03-04
Language en_AU
Research Centre Menzies Health Institute Qld; Heart Foundation Research Centre
Faculty Griffith Health Faculty
Subject Exercise Physiology; Molecular Targets
URI http://hdl.handle.net/10072/29773
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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