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dc.contributor.authorSuelz, Lorena
dc.contributor.authorAstorga, Guadalupe
dc.contributor.authorBellette, Bernadette
dc.contributor.authorIturriaga, Rodrigo
dc.contributor.authorMackay-Sim, Alan
dc.contributor.authorBacigalupo, Juan
dc.contributor.editorJack R. Lancaster, Takaaki Akaike, Ulrich Förstermann, Joshua M. Hare
dc.date.accessioned2017-05-03T15:24:42Z
dc.date.available2017-05-03T15:24:42Z
dc.date.issued2009
dc.date.modified2010-06-24T05:18:25Z
dc.identifier.issn1089-8603
dc.identifier.doi10.1016/j.niox.2009.01.004
dc.identifier.urihttp://hdl.handle.net/10072/30159
dc.description.abstractThe study of Parkinson's disease (PD), like other complex neurodegenerative disorders, is limited by access to brain tissue from patients with a confirmed diagnosis. Alternatively the study of peripheral tissues may offer some insight into the molecular basis of disease susceptibility and progression, but this approach still relies on brain tissue to benchmark relevant molecular changes against. Several studies have reported whole-genome expression profiling in post-mortem brain but reported concordance between these analyses is lacking. Here we apply a standardised pathway analysis to seven independent case-control studies, and demonstrate increased concordance between data sets. Moreover data convergence increased when the analysis was limited to the five substantia nigra (SN) data sets; this highlighted the down regulation of dopamine receptor signaling and insulin-like growth factor 1 (IGF1) signaling pathways. We also show that case-control comparisons of affected post mortem brain tissue are more likely to reflect terminal cytoarchitectural differences rather than primary pathogenic mechanisms. The implementation of a correction factor for dopaminergic neuronal loss predictably resulted in the loss of significance of the dopamine signaling pathway while axon guidance pathways increased in significance. Interestingly the IGF1 signaling pathway was also over-represented when data from non-SN areas, unaffected or only terminally affected in PD, were considered. Our findings suggest that there is greater concordance in PD wholegenome expression profiling when standardised pathway membership rather than ranked gene list is used for comparison.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUSA
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom238
dc.relation.ispartofpageto252
dc.relation.ispartofissue4
dc.relation.ispartofjournalNitric Oxide - Biology and Chemistry
dc.relation.ispartofvolume20
dc.rights.retentionN
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.titleNitric oxide regulates neurogenesis in adult olfactory epithelium in vitro
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, School of Natural Sciences
gro.date.issued2009
gro.hasfulltextNo Full Text
gro.griffith.authorMackay-Sim, Alan


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