The synthesis of biotinylated carbohydrates as probes for carbohydrate-recognizing proteins

There are no files associated with this record.

Title The synthesis of biotinylated carbohydrates as probes for carbohydrate-recognizing proteins
Author Kiefel, Milton; von Itzstein, Mark; Angus, Donald I.
Journal Name Bioorganic & Medicinal Chemistry
Year Published 2000
Place of publication UK
Publisher Pergamon
Abstract The intimate involvement of carbohydrateprotein interactions in a number of important biological processes has prompted several research efforts towards developing new methods of investigating these glycobiological interactions. Biotinylated oligosaccharides are emerging as a new and powerful tool in this area of research, primarily due to their high affinity towards streptavidin and their ease of immobilization on matrices. Here we describe a novel synthetic approach towards biotinylated saccharides which incorporate a UV absorbing group into the final compounds. The synthetic strategy described is applicable to a variety of saccharides, with examples of biotinylated mono-, di-, and trisaccharides being prepared with overall high efficiency.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.elsevier.com/wps/find/journaldescription.cws_home/129/description#description
Copyright Statement Copyright 2000 Elsevier : Reproduced in accordance with the copyright policy of the publisher : This journal is available online - use hypertext links.
Volume 8
Page from 2709
Page to 2718
ISSN 0968-0896
Date Accessioned 2001-01-01
Date Available 2007-03-13T21:56:38Z
Language en_AU
Research Centre Institute for Glycomics
Subject Organic Chemical Synthesis
URI http://hdl.handle.net/10072/3016
Publication Type Article in Scholarly Refereed Journal
Publication Type Code c1

Brief Record

Griffith University copyright notice