Olfactory Dysfunction is Associated with Subjective Memory Complaints in Community-Dwelling Elderly Individuals

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Title Olfactory Dysfunction is Associated with Subjective Memory Complaints in Community-Dwelling Elderly Individuals
Author Sohrabi, Hamid R.; Bates, Kristyn A.; Rodrigues, Mark; Taddei, Kevin; Laws, Simon M.; Lautenschlager, Nicola T.; Dhaliwal, Satvinder S.; Johnston, Amy Nicole Burne; Mackay-Sim, Alan; Gandy, Samuel; Foster, Jonathan K.; Martins, Ralph N.
Journal Name Journal of Alzheimer's Disease
Editor Dr. George Perry, Mark A Smith
Year Published 2009
Place of publication Netherlands
Publisher IOS Press
Abstract Olfactory dysfunction has been reported in clinical and preclinical phases of Alzheimer's disease. Subjective memory complaints have been proposed as a potential early indicator for increased risk of Alzheimer's disease, but have also been associated with depression, personality characteristics, and health problems. In this study, we aimed to determine which of these putative markers can predict memory complaints in community-dwelling elderly individuals, focusing on olfactory symptoms. A cohort of 144 elderly volunteers (42 males and 102 females), aged 50 to 86, was recruited from an ongoing longitudinal study. Participants were assessed for olfactory capacities (threshold, discrimination, and identification), subjective memory complaints, depression, and cognitive functions. Subjective memory complaints were significantly associated with olfactory discrimination and identification but not with threshold. Olfactory functions and depressive symptoms were both significantly associated with subjective memory complaints. In addition, memory complainers were significantly worse than non-complainers with respect to olfactory discrimination, identification, and overall olfactory functioning. The findings suggest that olfactory capacity may be a potentially significant biomarker for identifying community-dwelling elderly with memory complaints who are at increased risk for age-related cognitive decline and Alzheimer's disease.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.3233/JAD-2009-1020
Volume 17
Issue Number 1
Page from 135
Page to 142
ISSN 1387-2877
Date Accessioned 2009-10-12
Language en_AU
Research Centre Centre for Health Practice Innovation; Eskitis Institute for Drug Discovery
Faculty Faculty of Science, Environment, Engineering and Technology
Subject PRE2009-Mental Health; PRE2009-Sensory Systems
URI http://hdl.handle.net/10072/30347
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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