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dc.contributor.authorSohrabi, Hamid R
dc.contributor.authorBates, Kristyn A
dc.contributor.authorRodrigues, Mark
dc.contributor.authorTaddei, Kevin
dc.contributor.authorLaws, Simon M
dc.contributor.authorLautenschlager, Nicola T
dc.contributor.authorDhaliwal, Satvinder S
dc.contributor.authorJohnston, Amy NB
dc.contributor.authorMackay-Sim, Alan
dc.contributor.authorGandy, Samuel
dc.contributor.authorFoster, Jonathan K
dc.contributor.authorMartins, Ralph N
dc.contributor.editorDr. George Perry, Mark A Smith
dc.date.accessioned2017-05-03T15:24:43Z
dc.date.available2017-05-03T15:24:43Z
dc.date.issued2009
dc.date.modified2010-08-19T07:05:00Z
dc.identifier.issn1387-2877
dc.identifier.doi10.3233/JAD-2009-1020
dc.identifier.urihttp://hdl.handle.net/10072/30347
dc.description.abstractOlfactory dysfunction has been reported in clinical and preclinical phases of Alzheimer's disease. Subjective memory complaints have been proposed as a potential early indicator for increased risk of Alzheimer's disease, but have also been associated with depression, personality characteristics, and health problems. In this study, we aimed to determine which of these putative markers can predict memory complaints in community-dwelling elderly individuals, focusing on olfactory symptoms. A cohort of 144 elderly volunteers (42 males and 102 females), aged 50 to 86, was recruited from an ongoing longitudinal study. Participants were assessed for olfactory capacities (threshold, discrimination, and identification), subjective memory complaints, depression, and cognitive functions. Subjective memory complaints were significantly associated with olfactory discrimination and identification but not with threshold. Olfactory functions and depressive symptoms were both significantly associated with subjective memory complaints. In addition, memory complainers were significantly worse than non-complainers with respect to olfactory discrimination, identification, and overall olfactory functioning. The findings suggest that olfactory capacity may be a potentially significant biomarker for identifying community-dwelling elderly with memory complaints who are at increased risk for age-related cognitive decline and Alzheimer's disease.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherIOS Press
dc.publisher.placeNetherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom135
dc.relation.ispartofpageto142
dc.relation.ispartofissue1
dc.relation.ispartofjournalJournal of Alzheimer's Disease
dc.relation.ispartofvolume17
dc.rights.retentionN
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchCognitive and computational psychology
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode5204
dc.titleOlfactory Dysfunction is Associated with Subjective Memory Complaints in Community-Dwelling Elderly Individuals
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2009
gro.hasfulltextNo Full Text
gro.griffith.authorMackay-Sim, Alan


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