Variant metabolic risk factor profile leading to premature coronary disease: time to define the syndrome of accelerated atherocoronary metabolic syndrome in Asian Indians

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Title Variant metabolic risk factor profile leading to premature coronary disease: time to define the syndrome of accelerated atherocoronary metabolic syndrome in Asian Indians
Author Jayasinghe, Satyajit Rohan; H, Jayasinghe S
Journal Name Singapore Medical Journal
Year Published 2009
Place of publication Singapore
Publisher Singapore Medical Association
Abstract Coronary artery disease (CAD) is fast becoming a major morbidity and mortality burden in the developing world. The magnitude of the problem is predicted to exceed that of the developed world due to the sheer population numbers at risk. The Indian subcontinental ethnicity has been associated with a more severe form of CAD that has its onset at a younger age. This form of coronary disease and its risk factors seem quite different from what has been previously described in studies done among non-Asian Indian populations (mainly Caucasians living in the West). This fact has led to a situation where the current preventative and management protocols that have worked well in the non-Asian Indian populations, have failed to bring about the anticipated control over this disease condition, its progression and its incidence in this population. The time has come to identify the variant of CAD in the Asian Indian ethnic population and the associated metabolic factors, as a separate and distinct entity, and as a unique syndrome. This distinction may facilitate more focused and ethnicity-specific studies to be carried out to unravel the mysteries surrounding the clinical, pathological and molecular biological aspects of the CAD syndrome among Asian Indian ethnics. The outcomes and findings of such investigations may help gain a stranglehold on this rapidly-progressing disease condition among the populations in emerging and densely-populated economies of the South Asian region, as well as among millions of Asian-Indian ethnics living all over the world. Thus we may brace ourselves to better address or even prevent what has been dubbed “the next major clinical epidemic of our times”.
Peer Reviewed Yes
Published Yes
Alternative URI http://smj.sma.org.sg/smjmainpages/5010main.html
Volume 50
Issue Number 10
Page from 949
Page to 955
ISSN 0037-5675
Date Accessioned 2009-12-08
Date Available 2010-07-26T06:52:29Z
Language en_AU
Faculty Griffith Health Faculty
Subject Medical and Health Sciences
URI http://hdl.handle.net/10072/30601
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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