Cytotoxic effects of Bangladeshi medicinal plant extracts

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Title Cytotoxic effects of Bangladeshi medicinal plant extracts
Author Uddin, Shaikh Jamal; Grice, Darren; Tiralongo, Evelin
Journal Name Evidence - Based Complementary and Alternative Medicine
Editor Prof. Dr Edwin L. Cooper
Year Published 2011
Place of publication United Kingdom
Publisher Oxford University Press
Abstract To investigate the cytotoxic effect of some Bangladeshi medicinal plant extracts, sixteen Bangladeshi medicinal plants were successively extracted with n-hexane, dichloromethane, methanol and water. The methanolic and aqueous extracts were screened for cytotoxic activity against healthy mouse fibroblasts (NIH3T3) and three human cancer cell lines (gastric: AGS; colon: HT-29; and breast: MDA-MB-435S) using the MTT assay. Two methanolic extracts (Hygrophila auriculata and Hibiscus tiliaceous) and one aqueous extract (Limnophila indica) showed no toxicity against healthy mouse fibroblasts, but selective cytotoxicity against breast cancer cells (IC50 1.1-1.6 mg/mL). Seven methanolic extracts from Limnophila indica, Clerodendron inerme, Cynometra ramiflora, Xylocarpus moluccensis, Argemone mexicana, Ammannia baccifera and Acrostichum aureum and four aqueous extracts from Hygrophila auriculata, Bruguiera gymnorrhiza, Xylocarpus moluccensis and Aegiceras corniculatum showed low toxicity (IC50 >2.5 mg/mL) against mouse fibroblasts but selective cytotoxicity (IC50 0.2-2.3 mg/mL) against different cancer cell lines. The methanolic extract of Blumea lacera showed the highest cytotoxicity (IC50 0.01-0.08 mg/mL) against all tested cell lines among all extracts tested in this study. For some of the plants their traditional use as anti-cancer treatments correlates with the cytotoxic results, whereas, for others so far unknown cytotoxic activities were identified.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1093/ecam/nep111
Copyright Statement Copyright 2009 Oxford University Press. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Volume 2011
Page from 1
Page to 7
ISSN 1741-4288
Date Accessioned 2010-02-04
Language en_US
Research Centre Griffith Health Institute; Institute for Glycomics; Molecular Basis of Disease
Faculty Griffith Health Faculty
Subject Pharmacology and Pharmaceutical Sciences
URI http://hdl.handle.net/10072/30665
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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