Sialic acid dependence in rotavirus host cell invasion
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| Title | Sialic acid dependence in rotavirus host cell invasion |
|---|---|
| Author | Haselhorst, Thomas Erwin; Fleming, Fiona E; Dyason, Jeffrey Clifford; Hartnell, Regan David; Yu, Xing; Holloway, Gavan; Santegoets, Kim; Kiefel, Milton; Blanchard, Helen; Coulson, Barbara S; von Itzstein, Mark |
| Journal Name | Nature Chemical Biology |
| Year Published | 2009 |
| Place of publication | USA |
| Publisher | Nature Publishing Group |
| Abstract | We used NMR spectroscopy, molecular modeling and infectivity competition assays to investigate the key interactions between the spike protein (VP8*) from 'sialidase-insensitive' human Wa and 'sialidase-sensitive' porcine CRW-8 rotaviruses and the glycans of gangliosides GM1 and GD1a. Our data provide strong evidence that N-acetylneuraminic acid is a key determinant for binding of these rotaviruses. This is in contrast to the widely accepted paradigm that sialic acids are irrelevant in host cell recognition by sialidase-insensitive rotaviruses. |
| Peer Reviewed | Yes |
| Published | Yes |
| Alternative URI | http://dx.doi.org/10.1038/nchembio.134 |
| Volume | 5 |
| Issue Number | 2 |
| Page from | 91 |
| Page to | 93 |
| ISSN | 1552-4450 |
| Date Accessioned | 2010-02-12 |
| Date Available | 2010-07-07T09:44:20Z |
| Language | en_AU |
| Research Centre | Institute for Glycomics |
| Faculty | Faculty of Science, Environment, Engineering and Technology |
| Subject | Characterisation of Biological Macromolecules |
| URI | http://hdl.handle.net/10072/31265 |
| Publication Type | Journal Articles (Refereed Article) |
| Publication Type Code | c1 |
Please use this identifier to cite this record: http://hdl.handle.net/10072/31265
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