Sialic acid dependence in rotavirus host cell invasion

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Title Sialic acid dependence in rotavirus host cell invasion
Author Haselhorst, Thomas Erwin; Fleming, Fiona E; Dyason, Jeffrey Clifford; Hartnell, Regan David; Yu, Xing; Holloway, Gavan; Santegoets, Kim; Kiefel, Milton; Blanchard, Helen; Coulson, Barbara S; von Itzstein, Mark
Journal Name Nature Chemical Biology
Year Published 2009
Place of publication USA
Publisher Nature Publishing Group
Abstract We used NMR spectroscopy, molecular modeling and infectivity competition assays to investigate the key interactions between the spike protein (VP8*) from 'sialidase-insensitive' human Wa and 'sialidase-sensitive' porcine CRW-8 rotaviruses and the glycans of gangliosides GM1 and GD1a. Our data provide strong evidence that N-acetylneuraminic acid is a key determinant for binding of these rotaviruses. This is in contrast to the widely accepted paradigm that sialic acids are irrelevant in host cell recognition by sialidase-insensitive rotaviruses.
Peer Reviewed Yes
Published Yes
Alternative URI
Volume 5
Issue Number 2
Page from 91
Page to 93
ISSN 1552-4450
Date Accessioned 2010-02-12
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Characterisation of Biological Macromolecules
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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