1 : 2 Adducts of copper(I) halides with 1,2-bis(di-2-pyridylphosphino)ethane: solid state and solution structural studies and antitumour activity

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Title 1 : 2 Adducts of copper(I) halides with 1,2-bis(di-2-pyridylphosphino)ethane: solid state and solution structural studies and antitumour activity
Author Bowen, Richard; Navarro, Maribel; Shearwood, Anne-Marie J.; Healy, Peter Conrad; Skelton, Brian W.; Filipovska, Aleksandra; Berners-Price, Sue
Journal Name Dalton Transactions
Year Published 2009
Place of publication United Kingdom
Publisher Royal Society of Chemistry
Abstract The 1 : 2 adducts of copper(I) halides with 1,2-bis(2-pyridylphosphino)ethane (d2pype) have been synthesized and solution properties characterized by variable temperature 1H, 31P and 65Cu NMR spectroscopy. Single-crystal structure determinations for the chloride, bromide and iodide complexes show these to crystallize from acetonitrile in the triclinic space group P¯1 as isostructural centrosymmetric dimers [(d2pype)Cu(m-d2pype)2Cu(d2pype)]X2· (solvent) with a ~ 12.6, b ~ 12.7, c ~15.3A˚ , a ~ 84, b ~ 67, g ~ 84◦. In contrast to the analogous AuCl:2(d2pype) and AgNO3:2(d2pype) adducts, in solution these CuX:2(d2pype) adducts (where X = Cl, Br and I) exist almost exclusively as bis-chelated monomeric [Cu(d2pype)2]X; evidence for an equilibrium between monomeric and dimeric forms is detected only for the CuCl adduct in methanol. Cytotoxicity studies in two human breast cancer lines and two matched liver progenitor cell lines indicate that [Cu(d2pype)2]Cl is non selectively toxic to both non-tumourigenic and tumourigenic cells. However, the analogous Au(I) compound [Au(d2pype)2]Cl, is toxic to highly tumourigenic cells and more selective in its toxicity to tumourigenic cells compared to non-tumourigenic cells. The significance of these results to the further development of selective, mitochondria-targeted, Au(I) antitumour complexes is discussed.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1039/b912281h
Volume 48
Issue Number N/A
Page from 10861
Page to 10870
ISSN 1477-9226
Date Accessioned 2010-02-19
Date Available 2010-07-07T09:44:22Z
Language en_AU
Research Centre Institute for Glycomics; Queensland Micro and Nanotechnology Centre
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Bioinorganic Chemistry
URI http://hdl.handle.net/10072/31266
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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